Mental health problems, stressful life events and new-onset urinary incontinence in primary school-age children: a prospective cohort study.
Mental health problems, stressful life events and new-onset urinary incontinence in primary school-age children: a prospective cohort study.
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小学学龄儿童的心理健康问题、压力生活事件和新发尿失禁：一项前瞻性队列研究。
DOI：
10.1007/s00787-023-02211-x
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发表时间：
2023
影响因子：
6.4
通讯作者：
Warne N
中科院分区：
文献类型：
--
作者：
Warne N
情绪/行为问题和暴露于紧张的生活事件被认为是导致新的尿失禁（UI）发作的儿童谁已经达到膀胱控制。然而，很少有前瞻性研究探讨了这些关联。我们在一个前瞻性的英国队列（n= 6408）中使用多变量logistic回归评估了精神健康问题和压力性生活事件是否与随后的UI新发相关。母亲提供了关于其子女常见精神障碍症状（发育和健康评估，7岁）、压力性生活事件（7-8岁）和尿床（白天和夜晚，9岁）的信息。在完全校正的模型中，有强有力的证据表明分离焦虑症状与新发UI相关（OR（95%CI）= 2.08（1.39，3.13），p< 0.001）。社交焦虑、注意力缺陷多动障碍和对立违抗性障碍症状与新发UI相关，但这些相关性在调整儿童发育水平和早期情绪/行为问题后减弱。有微弱的证据表明性与压力生活事件的相互作用（p= 0.065），因此，经历更多压力性生活事件的女性新发UI的风险更高（完全校正模型OR（95% CI）= 1.66（1.05，2.61），p= 0.029），但在男性中无相关性（完全校正模型OR（95% CI）= 0.87（0.52，1.47），p= 0.608）。这些结果表明，分离焦虑和紧张的生活事件的女孩可能会导致UI的增加。
Emotional/behaviour problems and exposure to stressful life events are thought to contribute to new onset of urinary incontinence (UI) amongst children who have attained bladder control. However, very few prospective studies have examined these associations. We assessed whether mental health problems and stressful life events were associated with subsequent new onset in UI using multivariable logistic regression in a prospective UK cohort (n= 6408). Mothers provided information on their child’s symptoms of common mental disorders (Development and Wellbeing Assessment, 7 years), stressful life events (7–8 years) and wetting (day and night, 9 years). There was strong evidence that separation anxiety symptoms were associated with new-onset UI in the fully adjusted model (OR (95% CI) = 2.08 (1.39, 3.13),p< 0.001). Social anxiety, attention-deficit hyperactivity disorder and oppositional defiant disorder symptoms were associated with new-onset UI, but these associations attenuated following adjustment for child developmental level and earlier emotional/behaviour problems. There was weak evidence for a sex interaction with stressful life events (p= 0.065), such that females experiencing more stressful life events were at higher risk of new-onset UI (fully adjusted model OR (95% CI) = 1.66 (1.05, 2.61),p= 0.029), but there was no association in males (fully adjusted model OR (95% CI) = 0.87 (0.52, 1.47),p= 0.608). These results suggest that separation anxiety and stressful life events in girls may lead to an increase in UI.