Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective.
Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective.
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DOI：
10.1016/j.ddmec.2007.10.005
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Gross, Garrett J
中科院分区：
文献类型：
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作者：
Gross, Eric R;Gross, Garrett J
心肌梗死是西方社会死亡率的主要原因，每年花费在人类冠状动脉疾病上的费用为4318亿美元。基于缺血预处理（IPC）的研究，对抗心肌损伤引起的梗死的治疗目前正在进行中。因此，本文综述了IPC的最新进展，包括IPC的一般和分子机制，以及IPC在衰老或疾病模型中的作用。本文还讨论了临床前和临床试验中显示具有疗效的治疗方法的总结以及心脏IPC研究的未来方向。
Myocardial infarction is the leading cause of mortality in Western societies with annual expenditures of $431.8 billion spent on coronary artery disease in man. Therapeutics to combat infarction from myocardial injury, based on studies of ischemic preconditioning (IPC), are currently in progress. Hence, this review provides an update on IPC, including general and molecular mechanisms responsible for IPC and the effects of IPC in models of aging or disease. A summary of therapeutics shown to possess efficacy in preclinical and clinical trials and future directions of studies regarding cardiac IPC are also discussed.