BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network
BNArray: an R package for constructing gene regulatory networks from microarray data by using Bayesian network
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DOI：
10.1093/bioinformatics/btl491
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发表时间：
2006-12-01
期刊：
影响因子：
5.8
通讯作者：
Ning, Kaida
中科院分区：
文献类型：
--
作者：
Chen, Xiaohui;Chen, Ming;Ning, Kaida
BNArray是r语言开发的一个系统化工具，它利用贝叶斯网络从DNA微阵列数据中构建基因调控网络。利用扩展的有向图子网络挖掘算法，重构了具有高置信度的调控网络的重要子模块。BNArray可以处理丢失数据的微阵列数据集。为了评估生成的贝叶斯网络的统计特征，利用重新采样过程产生候选一阶网络集的集合，用于挖掘密集相干子网络。
BNArray is a systemized tool developed in R. It facilitates the construction of gene regulatory networks from DNA microarray data by using Bayesian network. Significant sub-modules of regulatory networks with high confidence are reconstructed by using our extended sub-network mining algorithm of directed graphs. BNArray can handle microarray datasets with missing data. To evaluate the statistical features of generated Bayesian networks, re-sampling procedures are utilized to yield collections of candidate 1st-order network sets for mining dense coherent sub-networks.