Detection of circulating tumour cells enables early recurrence prediction in hepatocellular carcinoma patients undergoing liver transplantation
Detection of circulating tumour cells enables early recurrence prediction in hepatocellular carcinoma patients undergoing liver transplantation
复制标题
检测循环肿瘤细胞可以对接受肝移植的肝细胞癌患者进行早期复发预测。
DOI：
10.1111/liv.14734
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发表时间：
2020-11-29
影响因子：
6.7
通讯作者：
Yang, Xin-Rong
中科院分区：
文献类型：
--
作者：
Wang, Peng-Xiang;Xu, Yang;Yang, Xin-Rong
背景与目的肝移植（LTx）是治疗肝细胞癌（HCC）最有效的治疗方法之一;然而，LTx后肿瘤复发往往导致预后不佳。本研究探讨了循环肿瘤细胞（CTC）的价值作为一个预测复发后LTx在HCC患者。方法本分析包括193例HCC患者接受LTx在我们的研究所，并接受术前和术后CTC检测; 38个被选为系列CTC监测。评估了CTC对HCC患者LTx后肿瘤复发的预测价值。结果总的来说，LTx后CTC负荷降低（P <0.05）。术后CTC计数>= 1/5 mL外周血被确定为预测LTx后肿瘤复发的潜在生物标志物，特别是在LTx前无法检测到CTC且肿瘤血清学生物标志物阴性的患者中。对于不符合米兰标准、加州大学弗朗西斯科分校（UCSF）标准或复旦标准的患者，术后CTC计数>= 1/5 mL血液的预测值仍保留（所有P <0.05）。此外，术后系列CTC检测可能是有用的，在手术后监测HCC recurrence.Conclusions CTC可能是一个有用的生物标志物，以评估复发风险，肝细胞癌患者LTx。基于CTC检测的评估可能会加强HCC的移植后管理，并提高LTx的治疗效果。
Background & Aims Liver transplantation (LTx) is one of the most effective treatments for hepatocellular carcinoma (HCC); however, tumour recurrence after LTx often leads to poor outcomes. This study investigated the value of circulating tumour cells (CTCs) as a predictor of recurrence following LTx in patients with HCC.Methods This analysis included 193 patients with HCC who underwent LTx at our institute and accepted pre- and post-operative CTC detection; 38 were selected for serial CTC monitoring. The predictive value of CTCs for tumour recurrence in patients with HCC following LTx was evaluated. Single-cell whole genome sequencing was used to characterize CTCs.Results Overall, the CTC burden decreased after LTx (P < .05). Post-operative CTC count >= 1 per 5 mL peripheral blood was identified as a potential biomarker for predicting tumour recurrence after LTx, especially in patients with no detectable CTCs prior to LTx and negative tumour serological biomarkers. The predictive value of post-operative CTC count >= 1 per 5 mL blood was retained in patients who did not meet the Milan criteria, University of California San Francisco (UCSF) criteria, or Fudan criteria (all P < .05). Furthermore, post-operative serial CTC detection may be useful in post-surgical surveillance for HCC recurrence.Conclusions CTCs may be a useful biomarker to evaluate recurrence risk following LTx in patients with HCC. Evaluation based on CTC detection may enhance the post-transplant management of HCC, and improve the therapeutic efficacy of LTx.