Hypervolemia induced by fluid ingestion at rest: effect of sodium concentration.
Hypervolemia induced by fluid ingestion at rest: effect of sodium concentration.
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静息时摄入液体引起的血容量过多：钠浓度的影响。
DOI：
10.1007/s00421-014-2933-7
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Nishiyasu T
中科院分区：
文献类型：
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作者：
.Sugihara A;Fujii N;Tsuji B;Watanabe K;Niwa T;Nishiyasu T
目的钠饮料用于防止体液流失。然而，高浓度的钠可能会导致胃肠道不适（例如腹泻）。我们试图确定在胃肠道紊乱风险最小的情况下诱发高血容量的钠浓度。方法八名健康活跃的男性坐在椅子上，每隔 10 分钟分 6 等份摄入一定量（16−17 ml kg 体重−1）的水 (W) 或含有 60、120 或 180 mmol l−1Na+ 的溶液（60、120 和 180Na 试验）。为了标准化他们的水合状态，受试者在每次试验前 2 小时摄入相同的食物和水。饮酒试验是在不同的日子进行的，并且顺序是随机的。在开始饮酒后的 150 分钟内，根据每 30 分钟的血红蛋白浓度和血细胞比容估计血浆容量 (PV) 相对于饮酒前状态的变化。结果受试者在水合状态下开始试验，如血浆渗透压所反映的那样（以 mmol l−1:W 为单位，289.4 ± 1.4；60Na，287.0 ± 3.5；60Na，287.0 ± 3.5）。 120Na，287.6±2.3；180Na，288.9±3.3）。在 120 分钟时，W（-0.8±4.5％）或 60Na（2.4±4.9％）试验中的 PV 没有从饮用前的值增加，但在 120Na（7.2±4.6％）和 180Na（9.4±6.6％）试验中增加到相似程度。在 Wor 60Na 试验中没有报告腹泻，但在 120Na (n=1) 和 180Na(n=6) 试验中报告了腹泻。结论含有 120 mmol l−1Na+ 的饮料会引起血容量过多，而胃肠道问题的发生率最低。
PurposeSodium drink is used as a countermeasure against body fluid loss. However, high concentrations of sodium may cause gastrointestinal upset (e.g., diarrhea). We sought to determine the sodium concentration that induces hypervolemia with a minimal risk of gastrointestinal disturbance.MethodsEight healthy active males rested in a chair and ingested a given amount (16−17 ml kg body mass−1) of water (W) or solution containing 60, 120 or 180 mmol l−1Na+(60, 120 and 180Na trials) in 6 equal portions at 10 min intervals. To standardize their hydration status, subjects consumed the same meal and water 2 h before each trial. Drink trials were performed on separate days, and the order was randomized. The change in plasma volume (PV) from pre-drink status was estimated from the hemoglobin concentration and hematocrit every 30 min for 150 min after initiation of drinking.ResultsSubjects began trials in a euhydrated state, as reflected by their plasma osmolality (in mmol l−1:W, 289.4 ± 1.4; 60Na, 287.0 ± 3.5; 120Na, 287.6 ± 2.3; 180Na, 288.9 ± 3.3). At 120 min, PV had not increased from the pre-drink value in theW(−0.8 ± 4.5 %) or 60Na (2.4 ± 4.9 %) trials, but it increased to similar degrees in the 120Na (7.2 ± 4.6 %) and 180Na (9.4 ± 6.6 %) trials. No diarrhea was reported in theWor 60Na trials, but it was reported in the 120Na (n= 1) and 180Na (n= 6) trials.ConclusionsBeverages containing 120 mmol l−1Na+induce hypervolemia with a minimum incidence of gastrointestinal problems.