THE TRIER SOCIAL STRESS TEST - A TOOL FOR INVESTIGATING PSYCHOBIOLOGICAL STRESS RESPONSES IN A LABORATORY SETTING
THE TRIER SOCIAL STRESS TEST - A TOOL FOR INVESTIGATING PSYCHOBIOLOGICAL STRESS RESPONSES IN A LABORATORY SETTING
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DOI：
10.1159/000119004
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发表时间：
1993-01-01
影响因子：
3.2
通讯作者：
HELLHAMMER, DH
中科院分区：
文献类型：
--
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
本文介绍了一种在实验室环境中诱导适度心理应激的协议，并评估其对生理反应的影响。特里尔社会压力测试（Trier Social Stress Test，TSST）主要由预期期（10分钟）和测试期（10分钟）组成，在测试期内，受试者必须在观众面前发表自由演讲并进行心算。在六项独立的研究中，已经发现该方案引起ACTH、皮质醇（血清和唾液）、GH浓度的显著变化。催乳素以及心率的显著增加。至于唾液皮质醇水平，TSST可靠地导致高于基线2至4倍的升高，皮质醇浓度峰值相似。研究中，TSST诱导的皮质醇增加阐明了一些多个变量有助于肾上腺皮质应激反应的个体间差异。结果表明，性别，遗传和尼古丁的消费可以影响个人的压力反应的心理压力，而人格特质与皮质醇反应TSST刺激没有相关性。从这些数据中，我们得出结论，TSST可以作为一种工具，心理生物学研究。
This paper describes a protocol for induction of moderate psychological stress in a laboratory setting and evaluates its effects on physiological responses. The 'Trier Social Stress Test' (TSST) mainly consists of an anticipation period (10 min) and a test period (10 min) in which the subjects have to deliver a free speech and perform mental arithmetic in front of an audience. In six independent studies this protocol has been found to induce considerable changes in the concentration of ACTH, cortisol (serum and saliva), GH. prolactin as well as significant increases in heart rate. As for salivary cortisol levels, the TSST reliably led to 2- to 4-fold elevations above baseline with similar peak cortisol concentrations. Studies are summarized in which TSST-induced cortisol increases elucidated some of the multiple variables contributing to the interindividual variation in adrenocortical stress responses. The results suggest that gender, genetics and nicotine consumption can influence the individual's stress responsiveness to psychological stress while personality traits showed no correlation with cortisol responses to TSST stimulation. From these data we conclude that the TSST can serve as a tool for psychobiological research.