Bone marrow-derived stem cells initiate pancreatic regeneration
Bone marrow-derived stem cells initiate pancreatic regeneration
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DOI：
10.1038/nbt841
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发表时间：
2003-07-01
影响因子：
46.9
通讯作者：
Bhatia, M
中科院分区：
文献类型：
--
作者：
Hess, D;Li, L;Bhatia, M
我们发现，移植表达c-kit的成人骨髓源性细胞可降低链脲佐菌素诱导胰腺损伤小鼠的高血糖症。虽然胰腺的定量分析显示供体胰岛素阳性细胞的频率较低，但这些细胞在血糖降低开始时并不存在。相反，大多数移植细胞定位于导管和胰岛结构，并且它们的存在伴随着受体胰腺细胞的增殖，导致胰岛素产生。移植的骨髓源性干细胞启动内源性胰腺组织再生的能力代表了一种以前未被认识到的方法，通过这种方法这些细胞可以促进器官功能的恢复。
We show that transplantation of adult bone marrow-derived cells expressing c-kit reduces hyperglycemia in mice with streptozotocin- induced pancreatic damage. Although quantitative analysis of the pancreas revealed a low frequency of donor insulin-positive cells, these cells were not present at the onset of blood glucose reduction. Instead, the majority of transplanted cells were localized to ductal and islet structures, and their presence was accompanied by a proliferation of recipient pancreatic cells that resulted in insulin production. The capacity of transplanted bone marrow-derived stem cells to initiate endogenous pancreatic tissue regeneration represents a previously unrecognized means by which these cells can contribute to the restoration of organ function.