Biocatalytic asymmetric Mannich reaction of ketimines using wheat germ lipase
Biocatalytic asymmetric Mannich reaction of ketimines using wheat germ lipase
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DOI：
10.1039/c5cy01923k
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发表时间：
2016-05
影响因子：
5
通讯作者：
Ling Wu;Yang Xiang;Da-cheng Yang;Zhi Guan;Yan‐Hong He
中科院分区：
文献类型：
--
作者：
Ling Wu;Yang Xiang;Da-cheng Yang;Zhi Guan;Yan‐Hong He
A highly enantioselective Mannich reaction between 3-substituted-2H-1,4-benzoxazines and acetone catalyzed by lipase from wheat germ type I (WGL) is described. Enantioselectivity of up to 95% ee was achieved in DMSO at 25 °C. This research provides a new and simple method for the synthesis of β-amino ketone derivatives and promotes the development of enzyme-catalyzed Mannich reactions.
