Animal models of Listeria infection.
Animal models of Listeria infection.
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DOI：
10.1002/9780471729259.mc09b01s10
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发表时间：
2008-08-01
影响因子：
--
通讯作者：
Cossart, Pascale
中科院分区：
文献类型：
--
作者：
Cabanes, Didier;Lecuit, Marc;Cossart, Pascale
单核细胞增多性李斯特菌是一种细胞内食源性病原体，可引起李斯特菌病，这是一种以胃肠炎、脑膜炎、脑炎和母婴感染为特征的感染。单核细胞增多性李斯特氏菌通过受污染的食物进入宿主，侵入小肠，转移到肠系膜淋巴结，并传播到肝、脾、脑，在孕妇中，传播到胎儿胎盘单位。已经开发了许多用于研究单核细胞增多性李斯特菌的致病试验，包括使用实验室动物进行的试验。一些小动物物种可以实验感染李斯特氏菌。小鼠和豚鼠可以通过胃内或静脉感染，通过计数感染目标器官内的细菌或通过评估50%致死量(LD50)来评估毒力。虽然小鼠和豚鼠可以通过多种途径感染李斯特菌，但胃内途径与人类食源性李斯特菌病的相关性最大。
Listeria monocytogenes is an intracellular foodborne pathogen that causes listeriosis, an infection characterized by gastroenteritis, meningitis, encephalitis, and maternofetal infections in humans. L. monocytogenes enters the host via contaminated foods, invades the small intestine, translocates to mesenteric lymph nodes, and spreads to the liver, spleen, brain and, in pregnant women, the fetoplacental unit. Many pathogenicity tests for studying L. monocytogenes have been developed, including tests using laboratory animals. A number of small animal species can be experimentally infected with Listeria. Mice and guinea pigs can be infected either intragastrically or intravenously, and virulence evaluated either by enumerating bacteria within infected target organs or by evaluating the 50% lethal dose (LD50). Although mice and guinea pigs can be infected with Listeria by a variety of routes, the intragastric route is the most relevant to the human foodborne listeriosis.