Antiviral antibodies are necessary to prevent ctotoxic T-lymphocyte escape in mice infected with a coronavirus
Antiviral antibodies are necessary to prevent ctotoxic T-lymphocyte escape in mice infected with a coronavirus
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DOI：
10.1128/jvi.01580-07
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发表时间：
2007-12-01
影响因子：
5.4
通讯作者：
Perlman, Stanley
中科院分区：
文献类型：
--
作者：
Butler, Noah S.;Dandekar, Ajai A.;Perlman, Stanley
病毒衍生的CD8 T细胞表位内的突变可以有效地消除细胞毒性T淋巴细胞（CTL）识别并阻碍感染宿主中的病毒清除。这些所谓的“CTL逃逸变体病毒”通常在持续感染期间被选择，并且与快速疾病进展和增加的疾病严重性相关。在此，我们测试了抗病毒抗体介导的病毒复制抑制和随后的病毒清除是否是预防冠状病毒感染小鼠中CTL逃逸所必需的。我们发现，与野生型小鼠相比，B细胞缺陷小鼠不能有效地清除感染性病毒，均匀地发展临床疾病，并携带CTL逃逸变异病毒。这些数据直接证明了抗病毒抗体在保护免受CTL逃逸变体病毒的选择性生长中的关键作用。
Mutation within virus-derived CD8 T-cell epitopes can effectively abrogate cytotoxic T-lymphocyte (CTL) recognition and impede virus clearance in infected hosts. These so-called "CTL escape variant viruses" are commonly selected during persistent infections and are associated with rapid disease progression and increased disease severity. Herein, we tested whether antiviral antibody-mediated suppression of virus replication and subsequent virus clearance were necessary for preventing CTL escape in coronavirus-infected mice. We found that compared to wild-type mice, B-cell-deficient mice did not efficiently clear infectious virus, uniformly developed clinical disease, and harbored CTL escape variant viruses. These data directly demonstrate a critical role for antiviral antibody in protecting from the selective outgrowth of CTL escape variant viruses.