Fetal sex and preterm birth: are males at greater risk?
Fetal sex and preterm birth: are males at greater risk?
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DOI：
10.1093/humrep/17.10.2762
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发表时间：
2002-10-01
影响因子：
6.1
通讯作者：
Kaminski, M
中科院分区：
文献类型：
--
作者：
Zeitlin, J;Saurel-Cubizolles, MJ;Kaminski, M
背景：早产儿中男性过多的存在是很有趣的，因为它可以揭示早产的病因。可能的机制是体重增加，对妊娠并发症的易感性增加，与性别有关的生化过程和生育周期中的早期受孕。方法：我们在四个原始数据集中测量了胎儿性别与早产之间的关联，包括IMF后出生的队列，以及从已发表的出生体重参考文献中提取的20个人群。原始样品也进行了分析的模式的发病结果。在大多数人群中，早产和早期早产中的男性多于足月分娩，包括IVF分娩（比值比：1.09-1.24）。在两个黑人出生队列、一般人群中的诱导早产和IVF后的自发性分娩中未观察到男性过多。结论：即使知道受孕时间，男婴出生的比例也会随着妊娠期的增加而下降。这种男性过剩似乎是最强的自发性早产。通过医学风险因素研究早产儿的性别比例可能会澄清为什么在某些人群中没有男性过剩。必须考虑到产科决策可能会影响所指出生的性别比例。
BACKGROUND: The existence of a male excess among preterm births is interesting because it could shed light on the aetiology of preterm birth. Possible mechanisms are greater body weight, increased susceptibility to complications of pregnancy, sex-linked biochemical processes and earlier conception in the fertile cycle. METHODS: We measured the association between fetal sex and preterm birth in four original datasets, including a cohort of births after IMF, and 20 populations extracted from published birthweight references. The original samples were also analysed by mode of onset RESULTS. There were more males among preterm and early preterm births than among term births in most populations, including IVF births (odds ratio: 1.09-1.24). No male excess was observed for two cohorts of black births, induced preterm births in the general population, and spontaneous onset births after IVF. CONCLUSIONS: The proportion of male births declines with increasing gestation, even when time of conception is known. This male excess appears to be strongest for spontaneous preterm births. Studying the sex ratio of preterm births by medical risk factors may clarify why the male excess is absent in some populations. The possibility that obstetric decision-making affects the sex ratio of indicated births must be considered.