Evidence for strain specificity in cytotoxic T-lymphocyte-mediated, major histocompatibility complex class I-dependent killing of Theileria annulata-infected cells
Evidence for strain specificity in cytotoxic T-lymphocyte-mediated, major histocompatibility complex class I-dependent killing of Theileria annulata-infected cells
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DOI：
10.1007/s004360050455
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发表时间：
1998-07-01
影响因子：
2
通讯作者：
Ahmed, JS
中科院分区：
文献类型：
--
作者：
Conze, G;Campbell, JDM;Ahmed, JS
已发现用一种寄生虫菌株免疫抗环形泰勒虫的牛对不同寄生虫菌株的再攻击具有免疫力。然而，最近的证据表明，明显的菌株特异性已被记录在牛免疫减毒寄生虫感染的细胞。在这项研究中，主要组织相容性复合物I类限制性细胞毒性T淋巴细胞（CTL），一个主要的抗寄生虫效应机制的菌株特异性进行了检查。用Hissar（印度）菌株攻击后产生的CTL有效地裂解了感染该寄生虫菌株的自体细胞。然而，CTL对感染Gharb（摩洛哥）菌株的细胞的有效性较低，对Ankara（土耳其）菌株几乎没有反应性，这为针对T.环状的
Cattle immunised against Theileria annulata with one parasite strain have been found to be immune to re-challenge with different strains of the parasite. However, recent evidence of apparent strain specificity has been documented in cattle immunised with attenuated parasite-infected cells. In this study the strain specificity of major histocompatibility complex class I-restricted cytotoxic T-lymphocytes (CTL), a major anti-parasite effector mechanism, was examined. CTL generated following challenge with the Hissar (Indian) strain effectively lysed autologous cells infected with this strain of the parasite. However, CTL were less effective against cells infected with the Gharb (Moroccan) strain and showed virtually no reactivity against the Ankara (Turkish) strain, providing the first direct evidence for strain specificity in immune responses against T. annulata.