ANTIGENIC DIFFERENCES BETWEEN MATT HEMOLYTIC STREPTOCOCCI AND THEIR GLOSSY VARIANTS.
ANTIGENIC DIFFERENCES BETWEEN MATT HEMOLYTIC STREPTOCOCCI AND THEIR GLOSSY VARIANTS.
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DOI：
10.1084/jem.48.6.769
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发表时间：
1928-11-30
影响因子：
15.3
通讯作者：
Todd, E W
中科院分区：
文献类型：
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作者：
Lancefield, R C;Todd, E W
用四株溶血性链球菌的哑光和光泽免疫兔。沉淀素试验表明，无论是对小鼠有毒力还是对小鼠无毒力的麦特生物，制备的兔血清都含有类型特异性抗体，而针对完全降解的有光泽生物的血清则不含有类型特异性抗体。类型特异性抗体通过同源亚特生物的吸收从血清中去除，但不受同源有光泽生物的吸收的影响。对小鼠的被动保护实验表明，抗马特血清具有保护性和抗光泽血清的作用，对同源强毒生物的感染无保护作用。用麦特生物体接种小鼠，使它们对随后用同源毒力培养物感染具有免疫力；但用有光泽的生物体接种，没有建立主动免疫。
The matt and the glossy forms of four strains of hemolytic streptococci were used to immunize rabbits. Precipitin tests showed that rabbit sera prepared against matt organisms, whether virulent or avirulent for mice, contained type-specific antibody while sera prepared against completely degraded glossy organisms contained no type-specific antibody. Type-specific antibody was removed from the sera by absorption with homologous matt organisms but was unaffected by absorption with homologous glossy organisms. Passive protection experiments on mice showed that anti-matt sera were protective and anti-glossy sera non-protective against infection with homologous virulent organisms. Vaccination of mice with matt organisms rendered them immune to subsequent infection with homologous virulent cultures; but vaccination with glossy organisms established no active immunity.