DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort
DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort
复制标题
DOI：
10.1016/j.joca.2017.09.006
复制
发表时间：
2017-12-01
影响因子：
7
通讯作者：
Tobias, J. H.
中科院分区：
文献类型：
--
作者：
Faber, B. G.;Baird, D.;Tobias, J. H.
目的：利用x线片的统计形状模型（SSM）来探讨关节形状改变与髋关节骨关节炎（OA）之间的关系。我们的目的是将SSM应用于双能x线吸收仪（DXA）髋关节扫描，并在一个基于大量人群的队列中检查髋关节形状模式（hsm）、放射学髋关节OA （RHOA）和髋关节疼痛之间的关系。方法：在男性骨质疏松性骨折（mrs）研究的基线髋部DXA扫描上进行SSM。在4100名参与者中分析了4.6年后骨盆x线片显示的前10名hsm与流行RHOA之间的关系。RHOA定义为Croft评分>= 2。髋关节疼痛是基于走路时的疼痛，检查时的髋关节疼痛，以及西安大略和麦克马斯特大学关节炎指数（WOMAC）。结果：与RHOA相关的5例hsm表现为钳型或凸轮型畸形。hsm1（钳型畸形增加）与RHOA呈正相关[1.23(1.09,1.39)][优势比（OR）和95% CI]。hsm8（复位钳型畸形）与RHOA呈负相关[0.79(0.70,0.89)]。hsm10（凸轮型畸形增加）与RHOA呈正相关[1.21(1.07,1.37)]。HSM 3和HSM 4（凸轮型畸形减少）与RHOA呈负相关[分别为0.73（0.65,0.83）和0.82(0.73,0.93)]。HSM 3与检查疼痛[0.84(0.76,0.92)]、行走疼痛[0.88,(0.81,0.95)]、WOMAC评分[0.87(0.80,0.93)]呈负相关。结论：dxa衍生的髋关节形状测量与RHOA相关，并且在较小程度上与髋关节疼痛相关，可能反映了它们在髋关节OA发病机制中的作用。(C) 2017国际骨关节炎研究学会。Elsevier Ltd.出版。版权所有。
Objective: Statistical shape modelling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.Method: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score >= 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).Results: The five HSMs associated with RHOA showed features of either pincer-or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09, 1.39)] [odds ratio (OR) and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70, 0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07, 1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65, 0.83) and 0.82 (0.73, 0.93), respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76, 0.92)] and walking [0.88, (0.81, 0.95)], and to WOMAC score [0.87 (0.80, 0.93)].Conclusions: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA. (C) 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.