Identification of gentian violet concentration that does not stain oral mucosa, possesses anti-candidal activity and is well tolerated.
Identification of gentian violet concentration that does not stain oral mucosa, possesses anti-candidal activity and is well tolerated.
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DOI：
10.1007/s10096-010-1131-8
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发表时间：
2011-05
影响因子：
4.5
通讯作者：
Ghannoum, M. A.
中科院分区：
文献类型：
--
作者：
Jurevic, R. J.;Traboulsi, R. S.;Mukherjee, P. K.;Salata, R. A.;Ghannoum, M. A.
在资源有限的环境中，建议将龙胆紫（GV）用于hiv感染患者口腔念珠菌病的初始治疗。由于GV的染色作用，目前不使用GV。在这项研究中，我们研究了三种不同浓度的GV的染色能力，以确定不会引起染色的浓度。选择不引起染色的浓度，评估其物理稳定性和抗真菌活性。15名健康参与者被随机分配，每天用三种GV浓度（0.1%、0.0085%或0.00165%）中的一种冲洗两次，持续14天。在基线和治疗结束时进行口腔检查和口腔内摄影。参与者回答了一份评估不良事件的问卷。使用临床和实验室标准研究所的方法评估抗真菌活性。0.00165%浓度的GV对口腔黏膜无染色作用，耐受性良好。浓度为0.00165%的GV在一定温度下保存不同时间，具有稳定的抗真菌活性。浓度为0.00165%的龙胆紫溶液对口腔黏膜无染色作用，稳定性好，具有较强的抗真菌活性。
Gentian violet (GV) is recommended for initial treatment of oral candidiasis in HIV-infected patients in resource-limited settings. Currently GV is not used because of its staining effects. In this study, we investigated the staining capacity of three different concentrations of GV to determine a concentration that does not cause staining. The selected concentration that did not cause staining was evaluated for its physical stability and antifungal activity. Fifteen healthy participants were randomized to rinse twice daily for 14 days with one of three GV concentrations: 0.1%, 0.0085%, or 0.00165%. Oral examination and intra-oral photographs were performed at baseline and at the end of therapy. Participants responded to a questionnaire to assess adverse events. Antifungal activity was evaluated using the Clinical and Laboratory Standard Institute methodology. GV at a concentration of 0.00165% did not stain the oral mucosa and was well tolerated. GV at a concentration of 0.00165% was stable and possessed antifungal activity when stored at certain temperatures for different time periods. Gentian violet solution at the concentration of 0.00165% does not stain the oral mucosa, is stable and possesses potent antifungal activity.
DOI：
10.1016/j.ijantimicag.2007.11.008
发表时间：
2008-03-01
影响因子：
10.8
作者：
Traboulsi, Rana S.;Mukherjee, Pranab K.;Ghannoum, Mahmoud A.
通讯作者：
Ghannoum, Mahmoud A.