REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease
REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease
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DOI：
10.1212/wnl.59.4.585
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发表时间：
2002-08-27
期刊：
影响因子：
9.9
通讯作者：
Montplaisir, J
中科院分区：
文献类型：
--
作者：
Gagnon, JF;Bédard, MA;Montplaisir, J
目的：通过病史和多导睡眠图（PSG）记录，确定PD患者REM睡眠行为障碍（RBD）的频率，并进一步研究PD患者REM睡眠肌张力。背景：PD中RBD的报告发生率为15%至47%。然而，没有研究估计的频率RBD使用PSG记录或详细分析的特点，REM睡眠肌张力在一个大组的帕金森病患者。方法：对33例帕金森病患者和16例健康对照者进行研究。每名受试者都接受了结构化的临床访谈和PSG记录。REM睡眠的评分方法允许在无张力的情况下对REM睡眠进行评分。结果：三分之一的PD患者符合基于PSG记录的RBD诊断标准。这些病例中只有一半会被历史发现。33例PD患者中有19例（58%）有REM睡眠，但16例对照受试者中只有1例无肌张力。在这19例PD患者中，8例（42%）未出现RBD的行为表现，其病例可能代表与PD相关的RBD临床前形式。此外，在REM睡眠期间，PD患者的肌张力下降时间百分比低于健康对照受试者（60.1% vs 93.2%; p = 0.003）。结论：多导睡眠图显示PD患者多为无张力的RBD和REM睡眠。
Objective: To determine the frequency of REM sleep behavior disorder (RBD) among patients with PD using both history and polysomnography (PSG) recordings and to further study REM sleep muscle atonia in PD. Background: The reported occurrence of RBD in PD varies from 15 to 47%. However, no study has estimated the frequency of RBD using PSG recordings or analyzed in detail the characteristics of REM sleep muscle atonia in a large group of unselected patients with PD. Methods: Consecutive patients with PD (n = 33) and healthy control subjects (n = 16) were studied. Each subject underwent a structured clinical interview and PSG recording. REM sleep was scored using a method that allows the scoring of REM sleep without atonia. Results: One third of patients with PD met the diagnostic criteria of RBD based on PSG recordings. Only one half of these cases would have been detected by history. Nineteen (58%) of 33 patients with PD but only 1 of 16 control subjects had REM sleep without atonia. Of these 19 patients with PD, 8 (42%) did not present with behavioral manifestations of RBD, and their cases may represent preclinical forms of RBD associated with PD. Moreover, the percentage of time spent with muscle atonia during REM sleep was lower among patients with PD than among healthy control subjects (60.1% vs 93.2%; p = 0.003). Conclusions: RBD and REM sleep without atonia are frequent in PD as shown by PSG recordings.