SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis
SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis
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DOI：
10.1093/carcin/bgad009
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Shu Zhang
中科院分区：
文献类型：
--
作者：
Fanghua Chen;Ling Aye;Lei Yu;Longzi Liu;Yuming Liu;Youpei Lin;Dongmei Gao;Qiang Gao;Shu Zhang
Abstract. Protein tyrosine phosphatases (PTPs) are involved in malignant transformation and metastasis. According to one of our previous studies, Slingshot homolog 1 (SSH1), a member of PTPs, is significantly associated with the survival of intrahepatic cholangiocarcinoma (iCCA) patients. However, the underlying mechanisms of SSH1 in iCCA remain largely elusive. Here, the expression and clinical significance of SSH1 were assessed using the iCCA patient samples. The results showed that SSH1 was dramatically up-regulated in iCCA tissues and elevated SSH1 expression was associated with worse overall survival of iCCA patients. Overexpression of SSH1 accelerated the proliferation, migration and invasion of iCCA cells, and also inhibited cell apoptosis. Furthermore, the downstream signaling pathway of SSH1 in iCCA was explored and it was revealed that the increased expression of SSH1 could activate the p38 MAPK pathway and enhance the expression of CXCL8. Notably, the high correlation of SSH1 with CXCL8 jointly indicated the poor prognosis in iCCA patients. Thus, our study suggests SSH1 as a potentially promising target for iCCA, which promoted iCCA progression through a potential p38 MAPK-CXCL8 axis.
