Factors predictive of ten-year mortality in severe anorexia nervosa patients
Factors predictive of ten-year mortality in severe anorexia nervosa patients
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DOI：
10.1111/j.1600-0447.2010.01627.x
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发表时间：
2011-01-01
影响因子：
6.7
通讯作者：
Falissard, B.
中科院分区：
文献类型：
--
作者：
Huas, C.;Caille, A.;Falissard, B.
目的：对住院神经性厌食症患者的死亡率和预测因素知之甚少。本研究旨在通过住院治疗后10年的随访，在大样本成人中建立死亡率和确定预测因素。方法：对601名连续住院的神经性厌食症(DSM-IV)患者在入院时进行初步评估，建立生命状态。计算标化死亡率(SMR)。对假设的死亡率预测因素进行了Cox分析。结果：共记录了40例死亡病例。SMR为10.6[可信区间为95%(7.6~14.4)]。入院时死亡与6个因素有关：年龄大、进食障碍持续时间长、自杀未遂史、利尿剂使用、进食障碍症状强度和入院时期望的体重指数。结论：神经性厌食症住院患者死亡风险较高。这种风险可以通过住院期间疾病的慢性度和严重性来预测。这些因素应被视为调整护理规定的警告，并可作为治疗的目标。
Objective:Little is known concerning mortality and predictive factors for anorexia nervosa in-patients. This study aimed to establish mortality rates and identify predictors in a large sample of adults through a 10-year post in-patient treatment follow-up.Method:Vital status was established for 601 anorexia nervosa (DSM-IV) consecutive in-patients with initial evaluation at admission. Standardized mortality ratio (SMR) was calculated. Cox analyses for hypothesized predictors of mortality were performed.Results:Forty deaths were recorded. SMR was 10.6 [CI 95% (7.6-14.4)]. Six factors at admission were associated with death: older age, longer eating disorder duration, history of suicide attempt, diuretic use, intensity of eating disorder symptoms, and desired body mass index at admission.Conclusion:Anorexia nervosa in-patients are at high risk of death. This risk can be predicted by both chronicity and seriousness of illness at hospitalization. These elements should be considered as warnings to adapt care provision and could be targeted by treatment.