Hypomagnesemia and hypocalcemia in mycosis fungoides: a retrospective case series.
Hypomagnesemia and hypocalcemia in mycosis fungoides: a retrospective case series.
复制标题
蕈样肉芽肿中的低镁血症和低钙血症：回顾性病例系列。
DOI：
10.1080/10428190290026367
复制
发表时间：
2002
影响因子：
2.6
通讯作者：
Duvic,Madeleine
中科院分区：
文献类型：
--
作者：
Morgan,Matt;Maloney,Denise;Duvic,Madeleine
皮肤t细胞淋巴瘤（CTCLs）最常见的变体是蕈样真菌病（MF），这是一种非典型CD4 + CD45Ro + t细胞的恶性增殖，最初在皮肤中增殖，后来侵入淋巴结和其他器官，包括血液（Sezary综合征）。CTCL的发病机制在很大程度上是未知的。我们提出明确的数据显示低镁血症和低钙血症的程度和患病率与MF的临床分期之间的相关性。22.2%的早期MF患者（n= 27）、38.5%的中期患者（n= 13）和67.5%的晚期患者（n= 40）存在低镁血症。8.3%的早期MF患者（n= 24）、54.5%的中期患者（n= 11）和61.0%的晚期患者（n= 41）存在低钙血症。II期或更高MF患者与I期患者相比，低镁血症和低钙血症的比值比分别为5.33和16.24。低镁血症与免疫功能异常有关，包括大鼠t细胞白血病淋巴瘤的发展。我们推测低镁血症可能在MF或Sezary综合征（SS）的进展或发病机制中起作用。这一回顾性病例系列是首次报道人类血清阳离子与CTCL之间关系的研究。
The most common variant of cutaneous T-cell lymphomas (CTCLs) is mycosis fungoides (MF), a malignant proliferation of atypical CD4 + CD45Ro + T-cells that initially proliferate in the skin and later invades lymph nodes and other organs including the blood (Sezary syndrome). The pathogenesis of CTCL is largely unknown. We present definitive data showing a correlation between degree and prevalence of hypomagnesemia and hypocalcemia and clinical stage of MF. Hypomagnesemia was present in 22.2% of MF patients with early stage (n= 27), 38.5% of intermediate stage (n= 13), and 67.5% of advanced stage disease (n= 40). Hypocalcemia was present in 8.3% of MF patients with early stage (n= 24), 54.5% with intermediate stage (n= 11), and 61.0% with advanced stage disease (n= 41). The odds ratios for having hypomagnesemia and hypocalcemia in patients with stage II or higher MF compared with stage I patients were 5.33 and 16.24, respectively. Hypomagnesemia has been associated with immune function abnormalities including the development of T-cell leukemia–lymphoma in rats. We hypothesize that the hypomagnesemia may play a role in the progression or pathogenesis of MF or the Sezary syndrome (SS). This retrospective case series is the first study ever to report a relationship between serum cations and CTCL in humans.