T cell receptor-mediated signs and signals governing T cell development.
T cell receptor-mediated signs and signals governing T cell development.
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T 细胞受体介导的控制 T 细胞发育的体征和信号。
DOI：
10.1006/smim.1999.0179
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
vanOers,NS
中科院分区：
文献类型：
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作者：
vanOers,NS
T 细胞的发育命运很大程度上取决于前 T 细胞受体 (TCR) 和 TCR 复合物介导的信号的性质和成功。这些细胞内信号受到配体与前 TCR 或 TCR 复合物结合后启动的蛋白质酪氨酸磷酸化级联的调节。磷酸化级联主要由两个不同的蛋白酪氨酸激酶 (PTK) 家族（Src- 和 Syk/ZAP-70- 家族）精心策划。种系基因靶向实验、几种人类免疫缺陷和体细胞突变体都有助于我们了解这些激酶家族如何协调其作用以促进信号传导。激活后，PTK 将其信号传递给许多新描述的接头蛋白，包括 LAT、SLP-76 和 vav 等。以下综述结合了不同实验策略的结果，以检验 PTK 和接头分子对前 TCR 和 TCR 信号传导过程的贡献。
The developmental fate of T cells is largely controlled by the nature and success of signals mediated by the pre-T cell receptor (TCR) and TCR complexes. These intracellular signals are regulated by cascades of protein tyrosine phos- phorylations initiated following ligand binding to the pre-TCR or TCR complexes. The phosphorylation cascades are primarily orchestrated by two distinct families of protein tyrosine kinases (PTKs), the Src- and the Syk/ZAP-70- families. Germline gene targeting experiments, several hu- man immunodeficiencies, and somatic cell mutants have all contributed to our understanding of how these families of kinases coordinate their actions to promote signaling. Upon activation, the PTKs transmit their signals to a number of newly described adaptor proteins including LAT, SLP-76, and vav, among others. The following review combines results derived from different experimental strategies to ex- amine the contributions of the PTKs and the adaptor molecules to pre-TCR and TCR signaling processes.