Obesity in adolescents with chronic fatigue syndrome: an observational study.
Obesity in adolescents with chronic fatigue syndrome: an observational study.
复制标题
慢性疲劳综合征青少年的肥胖症：一项观察性研究。
DOI：
10.1136/archdischild-2016-311293
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发表时间：
2017-01
影响因子：
5.2
通讯作者：
Crawley E
中科院分区：
文献类型：
--
作者：
Norris T;Hawton K;Hamilton-Shield J;Crawley E
确定慢性疲劳综合征（CFS）患者与健康青少年的肥胖患病率，以及在人群队列中确定的CFS患者。多输入数据的横断面分析。来自英国儿童CFS/肌痛性脑脊髓炎（CFS/ME）服务的数据与雅芳父母和儿童纵向研究（ALSPAC）在两个时间点收集的数据进行比较。1685名青少年在2004年至2014年期间参加了CFS/ME专家服务，13978名年龄约为13岁和16岁的青少年参加了ALSPAC研究。体重指数（BMI） （kg/m2）、性别和年龄特异性BMI z分数（相对于国际肥胖工作组的截止值）和肥胖患病率（%）。与ALSPAC中被归类为CFS/ME的青少年（13岁：3.72%；16岁：5.46%）和ALSPAC中非CFS的青少年（13岁：4.18%；16岁：4.46%）相比，接受过CFS/ME专科服务的青少年肥胖患病率（13岁：9.28%；16岁：16.43%）更高。在接受专科治疗的患者中（相对于ALSPAC的非慢性疲劳综合症患者），肥胖的几率增加在13年（OR: 2.31(1.54至3.48)）和16年时都很明显，在16年时观察到的可能性更大（OR: 4.07(2.04至8.11)）。我们观察到青少年肥胖的患病率增加，这些青少年的影响严重到需要转介到专门的CFS/ME服务。为了确定这两种情况之间的时间关系，需要进一步的纵向研究。
Identify the prevalence of obesity in patients with chronic fatigue syndrome (CFS) compared with healthy adolescents, and those identified with CFS in a population cohort. Cross-sectional analysis of multiple imputed data. Data from UK paediatric CFS/myalgic encephalomyelitis (CFS/ME) services compared with data collected at two time points in the Avon Longitudinal Study of Parents and Children (ALSPAC). 1685 adolescents who attended a CFS/ME specialist service between 2004 and 2014 and 13 978 adolescents aged approximately 13 years and 16 years participating in the ALSPAC study. Body mass index (BMI) (kg/m2), sex-specific and age-specific BMI Z-scores (relative to the International Obesity Task Force cut-offs) and prevalence of obesity (%). Adolescents who had attended specialist CFS/ME services had a higher prevalence of obesity (age 13 years: 9.28%; age 16 years: 16.43%) compared with both adolescents classified as CFS/ME in ALSPAC (age 13 years: 3.72%; age 16 years: 5.46%) and those non-CFS in ALSPAC (age 13 years: 4.18%; age 16 years: 4.46%). The increased odds of obesity in those who attended specialist services (relative to non-CFS in ALSPAC) was apparent at both 13 years (OR: 2.31 (1.54 to 3.48)) and 16 years, with a greater likelihood observed at 16 years (OR: 4.07 (2.04 to 8.11)). We observed an increased prevalence of obesity in adolescents who were affected severely enough to be referred to a specialist CFS/ME service. Further longitudinal research is required in order to identify the temporal relationship between the two conditions.