CONTENT, SYNTHESIS, AND FUNCTION OF POLYAMINES IN TRYPANOSOMATIDS - RELATIONSHIP TO CHEMOTHERAPY
CONTENT, SYNTHESIS, AND FUNCTION OF POLYAMINES IN TRYPANOSOMATIDS - RELATIONSHIP TO CHEMOTHERAPY
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DOI：
10.1111/j.1550-7408.1981.tb02798.x
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
BACCHI, CJ
中科院分区：
文献类型：
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作者：
BACCHI, CJ
多胺是多胺取代的直链脂肪族；它们在不同组织中的含量差别很大，功能也很多。它们的主要生物合成途径来源于鸟氨酸和蛋氨酸。本文综述了鞭毛虫中多胺的含量和生物合成，重点介绍了它们在世界上大部分地区对人类具有致病性的寄生原生动物中可能作为关键药物靶点的作用。
Polyamines are multiply amine‐substituted straight‐chain aliphatics; their content in different tissues may vary widely, and their functions are many. Their main routes of biosynthesis originate from ornithine and methionine. Polyamine content and biosynthesis in tryposomatid flagellates are reviewed concluding with emphasis on their possible role as critical drug targets in these parasitic protozoa so pathogenic for man in large areas of the world.