CX3CL1/fractalkine enhances prostate cancer spinal metastasis by activating the Src/FAK pathway.
CX3CL1/fractalkine enhances prostate cancer spinal metastasis by activating the Src/FAK pathway.
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CX3CL1/fractalkine通过激活Src/FAK通路增强前列腺癌脊柱转移
DOI：
10.3892/ijo.2018.4487
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发表时间：
2018-10
影响因子：
5.2
通讯作者：
Dong J
中科院分区：
文献类型：
--
作者：
Liu P;Liang Y;Jiang L;Wang H;Wang S;Dong J
Chemokines serve important roles in the development of cancer. C-X3-C motif chemokine ligand 1 (CX3CL1) has been demonstrated to promote metastases in different types of tumors. The authors' previous studies demonstrated that the CX3CL1 (also termed fractalkine)/steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway is associated with spinal metastasis. In the present study, it was observed that CX3CL1/C-X3-C motif chemokine receptor 1 (CX3CR1) was overexpressed in prostate cancer tissues with spinal metastasis compared with primary tumors. Overexpression of CX3CR1 induced cell proliferation, migration and invasion, and inhibited cellular apoptosis. However, repression of CX3CR1 reduced cell proliferation, migration and invasion, and increased cellular apoptosis. In addition, the Src/FAK pathway was activated by CX3CL1, which depends on the Tyr992 residue of epidermal growth factor receptor (EGFR) for phosphorylation. The inhibitors of these kinases repressed the cell migration induced by CX3CL1 or CX3CR1 overexpression. Furthermore, overexpression of CX3CR1 induced the spinal metastasis of prostate cancer in an in vivo mouse model. Therefore, CX3CL1 and its regulation of the EGFR, Src and FAK pathways may be potential targets for the early prevention of spinal metastasis in prostate cancer.
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DOI：
10.4137/cgm.s12769
发表时间：
2013
期刊：
Cancer growth and metastasis
影响因子：
--
作者：
Dushyanthen S;Cossigny DA;Quan GM
通讯作者：
Quan GM
影响因子：
2.8
作者：
Figel, Sheila;Gelman, Irwin H.
通讯作者：
Gelman, Irwin H.
Fractalkine/CX3CL1及其受体在炎症和恶性疾病的发病机理中的作用，重点是B细胞恶性肿瘤。
影响因子：
4.6
作者：
Ferretti E;Pistoia V;Corcione A
通讯作者：
Corcione A
Fyn 通过促进体外 ROCK 激活介导高葡萄糖诱导的足细胞肌动蛋白细胞骨架重组
影响因子：
4.3
作者：
Lv Z;Hu M;Ren X;Fan M;Zhen J;Chen L;Lin J;Ding N;Wang Q;Wang R
通讯作者：
Wang R
影响因子：
4.5
作者：
Sarabia-Estrada, Rachel;Zadnik, Patricia L.;Sciubba, Daniel M.
通讯作者：
Sciubba, Daniel M.