Diagnostic and prognostic value of myeloid-related protein complex 8/14 for sepsis
Diagnostic and prognostic value of myeloid-related protein complex 8/14 for sepsis
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DOI：
10.1016/j.ajem.2015.06.025
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发表时间：
2015-09-01
影响因子：
3.6
通讯作者：
Liu, Guowei
中科院分区：
文献类型：
--
作者：
Gao, Shanglan;Yang, Yan;Liu, Guowei
目的：本研究旨在评价骨髓相关蛋白复合物8/14（MRP8/14）对重症监护病房脓毒症患者的诊断和预后价值。方法：纳入我院53例健康人、72例全身炎症反应综合征患者、74例脓毒症患者、78例严重脓毒症患者、76例感染性休克患者。采用酶联免疫吸附法检测血清MRP8/14，并计算入组时急诊科脓毒症死亡率（MEDS）评分。采用受试者工作特征曲线分析MRP8/14对脓毒症的诊断价值。将MRP8/14的预后价值与MEDS评分进行比较。所有患者均进行28天随访。结果:对照组、全身炎症反应综合征组、脓毒症组、严重脓毒症组、脓毒性休克组血清MRP8/14水平分别为(834.135±251.662)、(2343.213±901.850)、(3163.617±912.821)、分别为（3941.326 +/- 850.490）和（4131.326 +/- 950.439）ng/mL。骨髓相关蛋白复合物 8/14 水平随脓毒症严重程度而升高。脓毒症 MRP8/14 受试者工作特征曲线下面积为 0.901（95% 置信区间，0.852-0.942）。在预测 28 天死亡率方面，MRP8/14 的受试者工作特征曲线下面积大于 MEDS 评分。 28 天随访时，非幸存者的血清 MRP8/14 水平显着高于幸存者。此外，脓毒症合并急性肾损伤（AKI）患者的MRP8/14水平远高于无AKI的患者。 结论：髓样相关蛋白复合物8/14对于重症监护病房脓毒症和合并AKI的脓毒症患者的诊断和预后具有重要价值。 (C) 2015 Elsevier Inc. 保留所有权利。
Objective: The objective of this study is to evaluate the diagnostic and prognostic value of myeloid-related protein complex 8/14 (MRP8/14) in septic patients in intensive care units.Methods: Fifty-three cases of healthy people, 72 cases of systemic inflammatory response syndrome patients, 74 cases of sepsis patients, 78 cases of severe sepsis patients, and 76 cases of septic shock patients were enrolled in our hospital. Serum MRP8/14 was detected by enzyme-linked immunosorbent assay, and Mortality in Emergency Department Sepsis (MEDS) score was calculated at enrollment. The receiver operating characteristic curve was used to analyze the diagnostic value of MRP8/14 for sepsis. The prognostic values of MRP8/14 were compared with MEDS score. A 28-day follow-up was performed for all patients.Results: Serum MRP8/14 level of control group, systemic inflammatory response syndrome group, sepsis group, severe sepsis group, and septic shock group was (834.135 +/- 251.662), (2343.213 +/- 901.850), (3163.617 +/- 912.821), (3941.326 +/- 850.490), and (4131.326 +/- 950.439) ng/mL, respectively. Myeloid-related protein complex 8/14 level increased with sepsis severity. The area under the receiver operating characteristic curves of MRP8/14 for sepsis was 0.901 (95% confidence interval, 0.852-0.942). The area under the receiver operating characteristic curves of MRP8/14 was greater than that of MEDS score in predicting 28-day mortality. Serum MRP8/14 level was significantly higher in nonsurvivors than survivors at 28 days' follow-up. In addition, the level of MRP8/14 was much higher in septic patients with acute kidney injury (AKI) than those without AKI.Conclusions: Myeloid-related protein complex 8/14 is valuable for diagnosis and prognostication of sepsis and septic patients with AKI in the intensive care unit. (C) 2015 Elsevier Inc. All rights reserved.