More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture.
More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture.
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DOI：
10.12688/f1000research.12013.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Garrity PA
中科院分区：
文献类型：
--
作者：
van Giesen L;Garrity PA
离子型受体（IR）是离子型谷氨酸受体家族的一个分支，在无脊椎动物中作为感觉传导的重要介质。最近的工作表明，虽然最初作为嗅觉受体进行研究，但IR也介导了对味道，温度和湿度的检测。在这里，我们总结了最近的见解IR进化及其潜在的生态意义，以及最近的进展，我们的理解如何IR有助于不同的感觉方式。
The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates. Recent work shows that, though initially studied as olfactory receptors, the IRs also mediate the detection of taste, temperature, and humidity. Here, we summarize recent insights into IR evolution and its potential ecological significance as well as recent advances in our understanding of how IRs contribute to diverse sensory modalities.