Cyclic AMP oscillations in suspensions of Dictyostelium discoideum.
Cyclic AMP oscillations in suspensions of Dictyostelium discoideum.
复制标题
盘基网柄菌悬浮液中的环状 AMP 振荡。
DOI：
10.1098/rstb.1989.0005
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Othmer,HG
中科院分区：
文献类型：
--
作者：
Monk,PB;Othmer,HG
先前开发的用于细胞粘液霉菌盘基网柄菌中的信号传递和适应的模型可以解释细胞悬浮液中观察到的钙和环磷酸腺苷的振荡。给出的定性论证解释了振荡是如何产生的，并且数值计算显示了周期解的周期和幅度等特征如何取决于模型中的参数。研究了基本模型的几种扩展，包括细胞聚集的影响以及激活和适应过程中时间延迟的影响。还研究了混合细胞群的动力学，其中只有一小部分细胞能够自主振荡。
A model developed previously for signal relay and adaptation in the cellular slime mouldDictyostelium discoideumis shown to account for the observed oscillations of calcium and cyclic AMP in cellular suspensions. A qualitative argument is given which explains how the oscillations arise, and numerical computations show how characteristics such as the period and amplitude of the periodic solutions depend on parameters in the model. Several extensions of the basic model are investigated, including the effect of cell aggregation and the effect of time delays in the activation and adaptation processes. The dynamics of mixed cell populations in which only a small fraction of the cells are capable of autonomous oscillation are also studied.