CIGARETTE SMOKE - PROTECTION OF ALVEOLAR MACROPHAGES BY GLUTATHIONE AND CYSTEINE
CIGARETTE SMOKE - PROTECTION OF ALVEOLAR MACROPHAGES BY GLUTATHIONE AND CYSTEINE
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DOI：
10.1126/science.162.3855.810
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发表时间：
1968-01-01
期刊：
影响因子：
56.9
通讯作者：
GREEN, GM
中科院分区：
文献类型：
--
作者：
GREEN, GM
香烟烟雾对兔肺泡巨噬细胞吞噬细菌功能有定量抑制作用。每毫升香烟中添加0.2到0.4微摩尔的谷胱甘肽或半胱氨酸，这种吞噬细胞毒性作用就被消除了。血清蛋白既要有烟雾的毒性作用，又要有巯基化合物的保护作用。这些巯基化合物的保护作用表明，香烟烟雾对这些肺细胞具有氧化作用。
Phagocytosis of bacteria by rabbit alveolar macrophages is inhibited quantitatively by cigarette smoke in vitro. This phagocytoxic effect was abolished by addition of 0.2 to 0.4 micromole of glutathione or cysteine per milliliter of cigarette smoke. Serum protein was required to obtain both the toxic effect of the smoke and the protective action of the sulfhydryl compounds. The protective role of the sulfhydryl agents suggests an oxidant action of the cigarette smoke on these pulmonary cells.