Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins - The atherosclerosis risk in communities (ARIC) study
Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins - The atherosclerosis risk in communities (ARIC) study
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DOI：
10.1161/01.cir.98.3.204
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发表时间：
1998-07-21
期刊：
影响因子：
37.8
通讯作者：
Davis, CE
中科院分区：
文献类型：
--
作者：
Folsom, AR;Nieto, FJ;Davis, CE
背景-血浆总同型半胱氨酸(THcy)升高，维生素B摄入量低，以及与tHcy代谢相关的基因多态性可能在冠心病(CHD)中起作用。方法和结果：我们采用前瞻性病例队列设计来确定tHcy相关因素是否与中年男女平均3.3年的CHD发病率相关，年龄、种族和领域中心调整后的CHD发病率与CHD发病率呈正相关(P
Background-Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD). More prospective studies are needed.Methods and Results-We used a prospective case-cohort design to determine whether tHcy-related factors are associated with incidence of CHD over an average of 3.3 years of follow-up in a biracial sample of middle-aged men and women, Age-, race-, and field center-adjusted CHD incidence was associated positively (P