Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development
Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development
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DOI：
10.1111/cts.12531
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发表时间：
2018-03-01
影响因子：
3.9
通讯作者：
Austin, Christopher P.
中科院分区：
文献类型：
--
作者：
Wagner, John A.;Dahlem, Andrew M.;Austin, Christopher P.
药物发现和开发通常被图解为一个管道，尽管药物开发人员认为这是一种有用的过度简化，但这种地图可能会延续不准确的直接性概念，并且对于提高效率的过程工程来说作用甚微。为了创建更精细的模式，一组药物开发商、研究人员、患者权益倡导者和监管者开发了一个众包图集，其中包含将基本发现转化为健康干预措施所涉及的步骤，并注释了特别容易出现困难或失败的步骤。该药物发现、开发和部署图 (4DM) 提供了该过程的网络视图，这对于该领域的新手的沟通和教育、单个项目的定位和导航以及技术开发和重新设计工作的优先顺序以提高效率和效果非常有用。 4DM 可供整个翻译生态系统的利益相关者免费使用、修改和进一步开发。
Drug discovery and development is commonly schematized as a pipeline, and, although appreciated by drug developers to be a useful oversimplification, this cartology may perpetuate inaccurate notions of straightforwardness and is of minimal utility for process engineering to improve efficiency. To create a more granular schema, a group of drug developers, researchers, patient advocates, and regulators developed a crowdsourced atlas of the steps involved in translating basic discoveries into health interventions, annotated with the steps that are particularly prone to difficulty or failure. This Drug Discovery, Development, and Deployment Map (4DM), provides a network view of the process, which will be useful for communication and education to those new to the field, orientation and navigation of individual projects, and prioritization of technology development and re-engineering endeavors to improve efficiency and effectiveness. The 4DM is freely available for utilization, modification, and further development by stakeholders across the translational ecosystem.