Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds
Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds
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DOI：
10.1016/j.ejmech.2011.12.039
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发表时间：
2012-05-01
影响因子：
6.7
通讯作者：
Kumar, H. M. Sampath
中科院分区：
文献类型：
--
作者：
Jada, Srinivas;Doma, Mahendhar Reddy;Kumar, H. M. Sampath
合成了一系列新的厚朴酚衍生物，并进行了体外抗菌和抗增殖活性的评价。我们发现大多数化合物是金黄色葡萄球菌、MRSA和VRE的有效抑制剂，MIC在1-64 μ g/mL范围内，MBC在1-128 μ g/mL范围内。少数衍生物也表现出有前途的抗真菌活性。一些厚朴酚类似物表现出有前途的抗增殖活性比母体厚朴酚时，测试对三个人癌细胞系。(C)2012年Elsevier Masson SAS。All rights reserved.
A series of novel magnolol derivatives were synthesised and evaluated for in vitro antimicrobial and antiproliferative activities. We found that most of the compounds were effective inhibitors of Staphylococcus aureus, MRSA and VRE with MIC in the range of 1-64 mu g/mL and MBC in the range of 1-128 mu g/mL. Few derivatives also exhibited promising antifungal activity. Some magnolol analogues exhibited promising antiproliferative activity than parent magnolol when tested against three human cancer cell lines. (C) 2012 Elsevier Masson SAS. All rights reserved.