AACAP 2006 Research Forum-Advancing Research in Early-Onset Bipolar Disorder: Barriers and Suggestions
AACAP 2006 Research Forum-Advancing Research in Early-Onset Bipolar Disorder: Barriers and Suggestions
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DOI：
10.1089/cap.2008.100
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发表时间：
2009-02-01
影响因子：
1.9
通讯作者：
Tohen, Mauricio
中科院分区：
文献类型：
--
作者：
Carlson, Gabrielle A.;Findling, Robert L.;Tohen, Mauricio
目的：2006年研究论坛的目标是制定早发性双相情感障碍（EOBP）的研究议程，并通过了解导致其严重性和慢性化的风险和保护因素来改善结果。方法：五个工作组概述了EOBP遗传学、神经影像学、预防、心理社会因素和药物治疗方面的障碍和研究差距。人们一致认为，EOBP的定义和诊断缺乏共识是推进儿童和青少年BP研究的主要障碍。相关问题包括：在统计学和临床上管理共病的困难;获得足够的样本量来研究遗传学，生物学和治疗;了解EOBP的发展方面;并确定环境介质和风险和保护的主持人。同样，BP儿童的社会心理和药物治疗策略也受到诊断问题的阻碍。为了推进EOBP的研究，培训和资金机制需要开发这些issues in mind.Conclusions：EOBP构成了一个重大的公共卫生问题。障碍是重要的，但可以识别，因此不是不可克服的。为了促进对EOBP的理解，该领域必须致力于解决诊断和评估问题。一旦实现，有足够的人力和资金资源，研究领域的EOBP无疑将以快速的步伐前进。
Objective: The 2006 Research Forum addressed the goal of formulating a research agenda for early-onset bipolar disorder (EOBP) and improving outcome by understanding the risk and protective factors that contribute to its severity and chronicity.Method: Five work groups outlined barriers and research gaps in EOBP genetics, neuroimaging, prodromes, psychosocial factors, and pharmacotherapy.Results: There was agreement that the lack of consensus on the definition and diagnosis of EOBP is the primary barrier to advancing research in BP in children and adolescents. Related issues included: the difficulties in managing co-morbidity both statistically and clinically; acquiring adequate sample sizes to study the genetics, biology, and treatment; understanding the EOBP's developmental aspects; and identifying environmental mediators and moderators of risk and protection. Similarly, both psychosocial and medication treatment strategies for children with BP are hamstrung by diagnostic issues. To advance the research in EOBP, both training and funding mechanisms need to be developed with these issues in mind.Conclusions: EOBP constitutes a significant public health concern. Barriers are significant but identifiable and thus are not insurmountable. To advance the understanding of EOBP, the field must be committed to resolving diagnostic and assessment issues. Once achieved, with adequate personnel and funding resources, research into the field of EOBP will doubtless be advanced at a rapid pace.