Perivascular visceral adipose tissue induces atherosclerosis in apolipoprotein E deficient mice.
Perivascular visceral adipose tissue induces atherosclerosis in apolipoprotein E deficient mice.
复制标题
血管内内脏脂肪组织诱导载脂蛋白E缺乏小鼠的动脉粥样硬化。
DOI：
10.1016/j.atherosclerosis.2011.07.012
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发表时间：
2011-11
期刊：
影响因子：
5.3
通讯作者：
Eitzman, D. T.
中科院分区：
文献类型：
--
作者：
Oehman, M. K.;Luo, W.;Wang, H.;Guo, C.;Abdallah, W.;Russo, H. M.;Eitzman, D. T.
心外膜脂肪组织与冠状动脉疾病有关，但是血管周围脂肪组织与局部动脉粥样硬化形成之间的因果关系尚不清楚。载脂蛋白E缺陷（ApoE−/−）小鼠接受紧邻右颈总动脉的内脏或皮下脂肪组织移植。通过表面油红-O染色和横断面分析，对脂肪移植的颈动脉进行动脉粥样硬化分析。颈动脉的血管功能通过压力肌造影术进行评估。还对ApoE−/−小鼠进行内脏脂肪移植，并中和P-选择素糖蛋白配体-1（Psgl-1）。接受血管周围内脏脂肪的小鼠的动脉粥样硬化表面积和病变厚度大于皮下脂肪。内脏脂肪移植的小鼠也表现出更复杂的动脉粥样硬化病变，有动脉粥样硬化血栓形成的证据。与皮下移植相比，接受内脏脂肪移植的小鼠的血清Mcp-1更高。内脏脂肪移植也导致颈动脉内皮依赖性舒张功能受损。Psgl-1缺乏或用抗Psgl-1抗体中和Psgl-1对血管周围内脏脂肪组织诱导的动脉粥样硬化具有保护作用，并与Mcp-1水平降低相关。血管周围内脏脂肪导致内皮功能障碍和加速动脉粥样硬化。血管周围脂肪组织的这种促动脉粥样硬化作用通过Psgl-1的中和而被阻断。
picardial adipose tissue is associated with coronary artery disease, however the causal relationship between perivascular adipose tissue and local atherogenesis is unclear. Apolipoprotein E deficient (ApoE−/−) mice underwent transplantation of visceral or subcutaneous adipose tissue immediately adjacent to the right common carotid artery. Carotid arteries with fat transplants were analyzed for atherosclerosis by surface oil-red-O staining and cross-sectional analysis. Vascular function of the carotid arteries was assessed using pressure myography. Visceral fat transplants were also performed to ApoE−/− mice with neutralization of P-selectin glycoprotein ligand-1 (Psgl-1). Atherosclerosis surface area and lesion thickness were greater in mice receiving the perivascular visceral fat compared to the subcutaneous fat. Mice with visceral fat transplants also displayed more complicated atherosclerotic lesions with evidence of atherothrombosis. Serum Mcp-1 was higher in mice receiving visceral fat transplants compared to subcutaneous transplants. Visceral fat transplantation also caused impaired endothelial-dependent relaxation of the carotid artery. Psgl-1 deficiency or neutralization of Psgl-1 with an anti-Psgl-1 antibody was protective against perivascular visceral adipose tissue-induced atherosclerosis and was associated with reduced Mcp-1 levels. Perivascular visceral fat leads to endothelial dysfunction and accelerated atherosclerosis. This proatherogenic effect of perivascular adipose tissue is blocked by neutralization of Psgl-1.
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影响因子：
20.1
作者：
Russo HM;Wickenheiser KJ;Luo W;Ohman MK;Franchi L;Wright AP;Bodary PF;Núñez G;Eitzman DT
通讯作者：
Eitzman DT
影响因子：
8.3
作者：
Verlohren, S;Dubrovska, G;Gollasch, M
通讯作者：
Gollasch, M
影响因子：
20.1
作者：
Chatterjee TK;Stoll LL;Denning GM;Harrelson A;Blomkalns AL;Idelman G;Rothenberg FG;Neltner B;Romig-Martin SA;Dickson EW;Rudich S;Weintraub NL
通讯作者：
Weintraub NL
影响因子：
37.8
作者：
Ohman, Miina K.;Shen, Yuechun;Eitzman, Daniel T.
通讯作者：
Eitzman, Daniel T.
DOI：
10.1161/atvbaha.110.221705
发表时间：
2011-04-01
影响因子：
8.7
作者：
Withers, Sarah B.;Agabiti-Rosei, Claudia;Heagerty, Anthony M.
通讯作者：
Heagerty, Anthony M.