Stabilin-1 expression in tumor associated macrophages
Stabilin-1 expression in tumor associated macrophages
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DOI：
10.1016/j.brainres.2012.08.048
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发表时间：
2012-10-24
期刊：
影响因子：
2.9
通讯作者：
Wilson, Emma H.
中科院分区：
文献类型：
--
作者：
David, Clement;Nance, J. Philip;Wilson, Emma H.
多形性胶质母细胞瘤是一种非常具有侵袭性且常见的脑肿瘤。目前的治疗方法包括手术切除、化疗和放射治疗的组合。这些激烈的治疗目前的预后仍然是不到一年的中位生存期。由于这些治疗方法缺乏有效性，研究人员不得不寻找替代治疗方法。目前正在研究的一个重要替代方案是利用免疫系统直接瞄准并消除肿瘤细胞。 Stabilin-1 是巨噬细胞表达的一种清道夫受体，具有通过结合和内化富含半胱氨酸的酸性分泌蛋白 (SPARC) 来抑制肿瘤生长的潜力。 SPARC 已知在肿瘤微环境中上调，并参与细胞外基质重塑、细胞增殖和迁移。使用 siRNA 降低 SPARC 表达已被证明可以降低肿瘤侵袭性和存活率。我们研究了肿瘤环境中表达稳定蛋白 1 的免疫细胞的表型，并证明了肿瘤环境中表达稳定蛋白 1 的替代激活的巨噬细胞的短暂群体，以及随着肿瘤的进展该群体的消失。 (C) 2012 Elsevier B.V. 保留所有权利。
Glioblastoma multiforme is a very aggressive and common form of brain tumor. Current therapies consist of a combination of surgical removal, chemotherapy and radiation therapy. These drastic treatments still leave a current prognosis of median survival of less than 1 year. Lack of effectiveness of these treatments has left researchers looking for alternative forms of treatment. A significant alternative currently being investigated is the use of the immune system to potentially target and eliminate tumor cells directly. Stabilin-1, a scavenger receptor expressed by macrophages, has the potential in inhibiting tumor growth by binding and internalizing secreted protein acidic and rich in cysteine (SPARC). SPARC is known to be upregulated in the tumor microenvironment and is involved in extracellular matrix remodeling, cell proliferation and migration. Decreasing SPARC expression using siRNA has been shown to decrease tumor invasiveness and survival. We investigated the phenotype of stabilin-1 expressing immune cells in the tumor environment and demonstrated a transient population of alternatively activated macrophages expressing stabilin-1 in the tumor environment and the disappearance of that population as the tumor progresses. (C) 2012 Elsevier B.V. All rights reserved.