MUCIN GENE-EXPRESSION IN THE HUMAN ENDOCERVIX
MUCIN GENE-EXPRESSION IN THE HUMAN ENDOCERVIX
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DOI：
10.1093/humrep/10.1.98
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发表时间：
1995-01-01
影响因子：
6.1
通讯作者：
BOERSMA, A
中科院分区：
文献类型：
--
作者：
AUDIE, JP;TETAERT, D;BOERSMA, A
在人类子宫颈内膜中，研究的六种人类粘蛋白基因中有五种（MUC 2、MUC 3、MUC 4、MUC 5AC、MUC 5B和MUC 6）表达，而在一些其他粘膜中，杂交模式表明仅表达这些基因中的两种或三种。通过原位杂交获得的最强标记显著地与MUC 4一起获得，主要在黄体期，MUC 4基因的表达受雌孕激素比值的影响。在排卵周期中，MUC 4基因的表达变化与其它基因的表达变化差异不大。
In the human uterine endocervix, five out of the six human mucin genes investigated (MUC 2, MUC 3, MUC 4, MUC 5AC, MUC 5B and MUC 6) are expressed, whereas in some other mucosae the hybridization pattern demonstrates the expression of only two or three of these genes, The most intense labelling by in-situ hybridization is obtained significantly with MUC 4, predominantly during the luteal phase, The expression of the MUC 4 gene appears to be influenced by the oestro-progesterone ratio, During the ovulatory cycle, there are only a few differences concerning the variations of expression of all other MUC genes.