Alterations in the hemodynamic response function in congnitively impaired HIV/AIDS subjects
Alterations in the hemodynamic response function in congnitively impaired HIV/AIDS subjects
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DOI：
10.1016/j.jneumeth.2007.03.004
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发表时间：
2007-07-30
影响因子：
3
通讯作者：
Becker, James T.
中科院分区：
文献类型：
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作者：
Juengst, Shannon B.;Aizenstein, Howard J.;Becker, James T.
功能性磁共振成像（fMRI）揭示了HIV/AIDS患者中枢神经系统功能的改变。在这项研究中，我们比较了血氧水平依赖的血流动力学反应功能（BOLD HRF）信号在艾滋病毒/艾滋病和对照组作为一个必要的先决条件的fMRI研究更高层次的认知功能。使用事件相关功能磁共振成像，受试者进行了一个简单的感觉运动活动，允许测量的BOLD HRF在中央前回。有没有显着差异，在HRF被视为年龄，半球，或HIV血清状态的函数。然而，显着的结果后，划分的NIMH损害分类的主题。有16名对照受试者，19名正常/无症状神经心理障碍（ANT），11名轻微神经认知障碍（MNCD）/HIV相关性痴呆（HAD）受试者。MNCD/HAD受试者的HRF在16 s后没有恢复到基线，表明神经元功能的细微变化，这可能会影响事件相关的fMRI研究。(c)2007 Elsevier B.V.保留所有权利。
Functional magnetic resonance imaging (fMRI) has revealed much about altered CNS function in HIV/AIDS. In this study, we compared the blood oxygen level dependent hemodynamic response function (BOLD HRF) signal in HIV/AIDS and control subjects as a necessary pre-condition for fMRI studies of higher level cognitive function. Using event-related fMRI, subjects performed a simple sensory-motor activity allowing the measurement of the BOLD HRF in the precentral gyrus. There were no significant differences in the HRF when viewed as a function of age, hemisphere, or HIV serostatus. However, significant results were found after dividing the subjects by NIMH impairment classifications. There were 16 control subjects, 19 Normal/Asymptomatic Neuropsychological Impairment (ANT), and 11 Minor Neurocognitive Disorder (MNCD)/HIV-Associated Dementia (HAD) subjects. The HRF of MNCD/HAD subjects did not return to baseline after 16 s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies. (c) 2007 Elsevier B.V. All rights reserved.