Using ancient DNA and coalescent-based methods to infer extinction
Using ancient DNA and coalescent-based methods to infer extinction
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DOI：
10.1098/rsbl.2015.0822
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发表时间：
2016-02-01
期刊：
影响因子：
3.3
通讯作者：
Shapiro, Beth
中科院分区：
文献类型：
--
作者：
Chang, Dan;Shapiro, Beth
从保存下来的遗骸中提取的 DNA 序列可以为推断过去的种群动态增加相当大的分辨率。例如，基于聚结的方法已被用来将一些北极巨型动物种群的减少与上一个冰河时期的栖息地破碎化联系起来。然而，这些方法往往无法检测到灭绝前的种群数量下降，很可能是由于采样稀疏、遗传标记信息少，以及无法解释随着栖息地减少而日益结构化的种群性质的模型。随着古代 DNA 研究扩展到全基因组分析，这些数据将为环境变化的基因组后果和灭绝的遗传特征提供更高分辨率的解决方案。
DNA sequences extracted from preserved remains can add considerable resolution to inference of past population dynamics. For example, coalescent-based methods have been used to correlate declines in some arctic megafauna populations with habitat fragmentation during the last ice age. These methods, however, often fail to detect population declines preceding extinction, most likely owing to a combination of sparse sampling, uninformative genetic markers, and models that cannot account for the increasingly structured nature of populations as habitats decline. As ancient DNA research expands to include full-genome analyses, these data will provide greater resolution of the genomic consequences of environmental change and the genetic signatures of extinction.