Malignancies induced by chlorambucil.
Malignancies induced by chlorambucil.
复制标题
苯丁酸氮芥诱发的恶性肿瘤。
DOI：
10.1016/0305-7372(84)90004-5
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发表时间：
1984
影响因子：
11.8
通讯作者：
A. Denman
中科院分区：
文献类型：
--
作者：
R. Palmer;A. Denman
在接受苯丁酸氮芥治疗的患者中，急性髓性白血病的发病率很高。这似乎至少部分直接归因于药物本身，而不能归因于给予药物的疾病过程。结缔组织病患者可能比其他非恶性疾病患者对苯丁酸氮芥的致白血病作用更敏感。
There is a high incidence of acute myeloid leukaemia in patients who have been treated with chlorambucil. This appears at least in part to be directly due to the drug itself and cannot be attributed to the disease processes for which the drug is given. Patients with connective tissue diseases may be more sensitive to this leukaemogenic effect of chlorambucil than patients with other non-malignant conditions.