Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells.
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells.
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DOI：
10.1084/jem.185.3.461
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发表时间：
1997-02-03
影响因子：
15.3
通讯作者：
Flavell, R A
中科院分区：
文献类型：
--
作者：
Rincon, M;Anguita, J;Nakamura, T;Fikrig, E;Flavell, R A
白细胞介素（IL）-4是导致初始CD 4 + T细胞分化为T辅助细胞（Th）2表型的最有效因子，而IL-12和干扰素γ触发Th 1细胞的分化。然而，初始极化IL-4的来源仍不清楚。在这里，我们表明，IL-6，可能是由抗原呈递细胞分泌，是能够通过诱导初始生产的IL-4在CD 4 + T细胞中的初始CD 4 + T细胞的Th 2效应细胞。这些结果表明，由抗原呈递细胞响应特定病原体产生的细胞因子（IL-12或IL-6）的性质是决定免疫应答性质的关键因素。
Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to the T helper cell (Th) 2 phenotype, while IL-12 and interferon γ trigger the differentiation of Th1 cells. However, the source of the initial polarizing IL-4 remains unclear. Here, we show that IL-6, probably secreted by antigen-presenting cells, is able to polarize naive CD4+ T cells to effector Th2 cells by inducing the initial production of IL-4 in CD4+ T cells. These results show that the nature of the cytokine (IL-12 or IL-6), which is produced by antigen-presenting cells in response to a particular pathogen, is a key factor in determining the nature of the immune response.