A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation.
A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation.
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DOI：
10.1038/srep43522
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发表时间：
2017-03-02
影响因子：
4.6
通讯作者：
Koga Y
中科院分区：
文献类型：
--
作者：
Aoki R;Kamikado K;Suda W;Takii H;Mikami Y;Suganuma N;Hattori M;Koga Y
肠道微生物群是全球代谢综合征（MS）患病率的重要因素，其中包括肥胖和糖尿病。动物双歧杆菌抗多发性硬化症的作用。乳酸菌GCL2505 （BlaG）是一种在肠道中高度增殖的双歧杆菌菌株；longum JCM1217T （BloJ）进行了比较检验。BlaG治疗减少了内脏脂肪积累，提高了葡萄糖耐量，而BloJ对这些参数没有影响。肠道微生物分析显示，BlaG对肠道菌群整体细菌结构的影响强于BloJ，包括双歧杆菌属的富集。血浆和肠道中醋酸酯和胰高血糖素样肽-1水平均升高，而BloJ则无升高。相关分析表明，BlaG处理后肠道乙酸水平升高在BlaG诱导的抗ms作用中起关键作用。这些发现表明，BlaG是一种高活力和增殖性的益生菌，通过调节肠道微生物群来改善代谢紊乱，从而导致scfa，特别是醋酸盐的升高。
The gut microbiota is an important contributor to the worldwide prevalence of metabolic syndrome (MS), which includes obesity and diabetes. The anti-MS effects exerted by Bifidobacterium animalis ssp. lactis GCL2505 (BlaG), a highly proliferative Bifidobacterium strain in the gut, and B. longum ssp. longum JCM1217T (BloJ) were comparatively examined. BlaG treatment reduced visceral fat accumulation and improved glucose tolerance, whereas BloJ had no effect on these parameters. Gut microbial analysis revealed that BlaG exerted stronger effects on the overall bacterial structure of the gut microbiota than BloJ, including enrichment of the genus Bifidobacterium. The levels of acetate and glucagon-like peptide-1 were increased by BlaG treatment in both the gut and plasma, but not by BloJ treatment. Correlation analysis suggested that the elevation of gut acetate levels by BlaG treatment plays a pivotal role in the BlaG-induced anti-MS effects. These findings indicated that BlaG, a highly viable and proliferative probiotic, improves metabolic disorders by modulating gut microbiota, which results in the elevation of SCFAs, especially acetate.