Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study
Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study
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DOI：
10.1038/s41598-019-42365-w
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发表时间：
2019-04-15
影响因子：
4.6
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
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作者：
Hirabayashi, Mayo;Inoue, Manami;Tsugane, Shoichiro
幽门螺杆菌（H.幽门螺杆菌），胃癌的一个确定的危险因素，也被认为在胰腺癌的发展中发挥作用;然而，这种关联仍然没有定论。我们研究了日本男性和女性之间的这种联系。H.幽门螺杆菌和萎缩性胃炎（AG）的状态进行血清学检测，使用健康体检期间收集的血液样本。共有20，116例受试者入组了基于日本公共卫生中心的前瞻性研究队列II，并获得了H.幽门螺杆菌血清阳性（抗H. pylori）和AG被随访至2010年底。使用基线调查的信息，采用考克斯比例风险模型计算风险比（HR）和95%置信区间（CI）。在320，470人-年的随访中，确定了119例胰腺癌病例。没有观察到H.幽门螺杆菌和AG状态，独立或组合。在多变量校正模型中，我们观察到AG但抗H抗体的患者风险无显著降低。幽门螺杆菌血清阴性（HR 0.57，95% CI 0.31-1.03）。在分层分析中，我们观察到AG+（HR 3.64，95% CI 1.37-9.66）和AG+/抗H的胰腺癌风险在统计学上显著增加。pylori-或AG+/抗H。pylori+（HR 5.21，95% CI 1.14-23.87）。所有AG和抗H类别的非吸烟者。幽门螺杆菌感染的风险无统计学意义的降低。H.幽门螺杆菌感染、AG状态和吸烟状态。我们的研究结果表明H.在日本普通人群中，幽门螺杆菌血清阳性和AG单独或联合与胰腺癌风险无关。在目前的吸烟者中，胰腺癌的风险随着AG的增加而增加，与H无关。幽门螺杆菌感染状况。
Helicobacter pylori (H. pylori), an established risk factor for gastric cancer, is suggested to also play a role in the development of pancreatic cancer; however, the association remains inconclusive. We examined this association among Japanese men and women. H. pylori and atrophic gastritis (AG) status were determined serologically, using blood sample collected during health checkups. A total of 20,116 subjects enrolled in the Japan Public Health Center-based Prospective Study Cohort II with available data on H. pylori seropositivity (anti-H. pylori) and AG were followed until the end of 2010. Cox proportional hazards models were used to calculate the hazard ratios (HR) and 95% confidence intervals (CI), using the information from the baseline survey. During 320,470 person-years of follow-up, 119 cases of pancreatic cancer were identified. No statically significant increase or decrease in pancreatic cancer risk was observed for H. pylori and AG status, independently or in combination. In a multivariable-adjusted model, we observed a non-significant decrease in the risk among those who had AG but were anti-H. pylori seronegative (HR 0.57, 95% CI 0.31-1.03). In a stratified analysis, we observed a statistically significant increased risk of pancreatic cancer for AG+ (HR 3.64, 95% CI 1.37-9.66), and AG+/anti-H. pylori- or AG+/anti-H. pylori+ (HR 5.21, 95% CI 1.14-23.87) among current smokers. Non-smokers in all categories of AG and anti-H. pylori showed a non-statistical decrease in the risk. There was no statistically significant interaction between H. pylori infection, AG status, and smoking status. Our findings suggest H. pylori seropositivity and AG, individually or in combination, are not associated with the risk of pancreatic cancer in a general Japanese population. Among current smokers, pancreatic cancer risk increased with AG, regardless of H. pylori infection status.