Simultaneous imaging of in vivo conductivity and susceptibility.
Simultaneous imaging of in vivo conductivity and susceptibility.
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DOI：
10.1002/mrm.24759
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发表时间：
2014-03
影响因子：
3.3
通讯作者：
Liu, Chunlei
中科院分区：
文献类型：
--
作者：
Kim, Dong-Hyun;Choi, Narae;Gho, Sung-Min;Shin, Jaewook;Liu, Chunlei
关键词：
已经独立开发了使用MRI进行电导率和磁化率定量映射的方法。本研究的目的是提出一种方法，同时获得电导率和磁化率的信息，并根据这些属性产生图像。使用3D多回波梯度回波序列。在多回波期间的相位演变被用来产生定量磁化率图，而在零回波时间（TE）的相位值被检索，这被用来产生定量电导率图。进行电磁（EM）模拟，以评估由于电导率变化的相位分布。还采集了体模和体内数据，以评估所产生图像的质量。模拟表明，物体之间的相位差随着尺寸和电导率的增加而增加。对于准确的电导率估计，最大TE近似等于真实T2* 值，以实现信噪比最大化。当从电导率中分离相位贡献时，获得了最准确的磁化率。体模和体内结果显示代表EM特性的良好质量图像。一个同时定量EM属性成像方法在这里演示。该方法不仅提高了绘制电磁特性图的效率，而且可以通过分离电导率和磁化率引入的图像相位来提高磁化率图的精度。
Approaches for quantitative mapping of electric conductivity and magnetic susceptibility using MRI have been developed independently. The purpose of this study is to present a method to simultaneously acquire information on conductivity and susceptibility and to produce images based on these properties. A 3D multi-echo gradient-echo sequence was used. Phase evolution during the multi-echo was used to produce quantitative susceptibility maps, while the phase value at zero echo time (TE) was retrieved, which were used to generate quantitative conductivity maps. Electromagnetic (EM) simulations were performed to evaluate the phase distribution due to conductivity variations. Phantom and in vivo data were also acquired to assess the quality of images produced. Simulations demonstrated that phase differences across objects increase with size and conductivity. For an accurate conductivity estimate, the maximum TE was approximately equal to the true T2* value in order to achieve signal-to-noise ratio maximization. The most accurate susceptibility was obtained when separating phase contribution from conductivity. Phantom and in vivo results showed good quality images representing the EM properties. A simultaneous quantitative EM property imaging approach is demonstrated here. The approach not only improves the efficiency of mapping EM properties, but can also improve the accuracy of susceptibility mapping by separating image phases introduced by conductivity and susceptibility.
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影响因子：
3.5
作者：
FOSTER, KR;SCHEPPS, JL;SCHWAN, HP
通讯作者：
SCHWAN, HP
影响因子：
3.1
作者：
LU, Y;LI, B;YU, J
通讯作者：
YU, J
影响因子：
3.5
作者：
van den Bergen, Bob;Stolk, Christiaan C.;Van den Berg, Cornelis A. T.
通讯作者：
Van den Berg, Cornelis A. T.
影响因子：
3.5
作者：
Gabriel, S;Lau, RW;Gabriel, C
通讯作者：
Gabriel, C
影响因子：
5.7
作者：
Sadleir, R. J.;Grant, S. C.;Woo, E. J.
通讯作者：
Woo, E. J.