Innate lymphoid cells in lung infection and immunity
Innate lymphoid cells in lung infection and immunity
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DOI：
10.1111/imr.12712
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发表时间：
2018-10
影响因子：
8.7
通讯作者：
Christina Stehle;Daniela C Hernández;C. Romagnani
中科院分区：
文献类型：
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作者：
Christina Stehle;Daniela C Hernández;C. Romagnani
近年来，先天性淋巴样细胞（ILC）已成为感染期间粘膜表面保护和修复的关键介质。肺是一种暴露于大量微生物的动态粘膜组织，是呼吸道感染病原体的游乐场，这些病原体不仅是全球死亡的主要原因，而且还与合并症和生活质量下降有关。肺提供了一个丰富的微环境，以研究ILC在气道内的先天保护机制，揭示其独特的功能，不仅在健康，而且在疾病。在这篇综述中，我们讨论了肺ILC如何在保护免受病毒，寄生虫，细菌和真菌的挑战中发挥作用，沿着这种ILC介导的免疫机制。
In recent years, innate lymphoid cells (ILCs) have emerged as key mediators of protection and repair of mucosal surfaces during infection. The lung, a dynamic mucosal tissue that is exposed to a plethora of microbes, is a playground for respiratory infection‐causing pathogens which are not only a major cause of fatalities worldwide, but are also associated with comorbidities and decreased quality of life. The lung provides a rich microenvironment to study ILCs in the context of innate protection mechanisms within the airways, unraveling their distinct functions not only in health but also in disease. In this review, we discuss how pulmonary ILCs play a role in protection against viral, parasitic, bacterial, and fungal challenge, along with the mechanisms underlying this ILC‐mediated immunity.