The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases.
The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases.
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DOI：
10.1016/j.iac.2010.09.013
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发表时间：
2011-02
影响因子：
2.6
通讯作者：
Marshall, Gailen D., Jr.
中科院分区：
文献类型：
--
作者：
Marshall, Gailen D., Jr.
心理应激对免疫系统具有已知的影响，包括对效应器以及调节成分的影响。这导致对各种感染如普通感冒的易感性增加以及潜伏病毒再活化和对免疫调节回路的影响。这可能至少是解释应激和炎症性疾病活动之间已知不良关联的机制之一，也可能是病因学。在转化研究的这一领域的巨大挑战之一是定义与特定患者人群，理想情况下，个人的压力相关的风险。未来的研究必须包括识别和验证生物标志物，这些生物标志物可以对患者因各种形式和程度的心理压力而产生的不良免疫效应风险进行分类，以及这如何影响其炎症性疾病的进程。
Psychological stress has known effects on the immune system that include impact on effector as well as regulatory components. This results in increased susceptibility to various infections such as the common cold as well as latent virus reactivation and impact on immunoregulatory circuits. This may be at least one of the mechanisms that explains the known adverse associations between stress and inflammatory disease activity and, perhaps, etiology as well. One of the great challenges in this area of translational research is defining the risks associated with stress in specific patient populations and, ideally, individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.
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影响因子：
7
作者：
Roy-Byrne, Peter P.;Davidson, Karina W.;Stein, Murray B.
通讯作者：
Stein, Murray B.
影响因子：
15.1
作者：
Marshall, GD;Agarwal, SK;Morris, GJ
通讯作者：
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影响因子：
3.7
作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1196/annals.1351.006
发表时间：
2006-01-01
期刊：
BASIC AND CLINICAL ASPECTS OF NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES
影响因子：
--
作者：
Calcagni, Emanuele;Elenkov, Ilia
通讯作者：
Elenkov, Ilia