HALLUCINOGENIC AMPHETAMINE SELECTIVELY DESTROYS BRAIN-SEROTONIN NERVE-TERMINALS
HALLUCINOGENIC AMPHETAMINE SELECTIVELY DESTROYS BRAIN-SEROTONIN NERVE-TERMINALS
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DOI：
10.1126/science.4023719
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
SCHUSTER, C
中科院分区：
文献类型：
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作者：
RICAURTE, G;BRYAN, G;SCHUSTER, C
（±）-3，4-亚甲二氧基苯丙胺（MDA）是一种具有致幻活性的苯丙胺类似物，它能选择性地长期降低大鼠脑内5-羟色胺水平、5-羟色胺摄取位点数目和5-羟吲哚乙酸浓度。形态学研究表明，这些神经化学缺陷是由于5-羟色胺神经末梢变性。这些结果表明，MDA对大鼠5-羟色胺神经元具有毒性活性，并提出了一个问题，即暴露于MDA和相关的致幻安非他明是否会在人脑中产生5-羟色胺神经毒性。
(±)-3,4-Methylenedioxyamphetamine (MDA), an amphetamine analog with hallucinogenic activity, produced selective long-lasting reductions in the level of serotonin, the number of serotonin uptake sites, and the concentration of 5-hydroxyindoleacetic acid in rat brain. Morphological studies suggested that these neurochemical deficits were due to serotonin nerve terminal degeneration. These results show that MDA has toxic activity for serotonin neurons in rats and raise the question of whether exposure to MDA and related hallucinogenic amphetamines can produce serotonin neurotoxicity in the human brain.