Health Impact of Rotavirus Vaccination in Developing Countries: Progress and Way Forward
Health Impact of Rotavirus Vaccination in Developing Countries: Progress and Way Forward
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DOI：
10.1093/cid/civ1015
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发表时间：
2016-05-01
影响因子：
11.8
通讯作者：
Tate, Jacqueline E.
中科院分区：
文献类型：
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作者：
Parashar, Umesh D.;Johnson, Hope;Tate, Jacqueline E.
自2006年以来，两种轮状病毒疫苗已在全球100多个国家获得许可。截至2005年10月，这些疫苗已在79个国家的国家免疫规划中实施，其中包括36个有资格获得疫苗联盟支持购买疫苗的低收入国家。轮状病毒疫苗最初是在澳大利亚以及美洲和欧洲国家成功完成临床试验后引进的，常规疫苗接种对减轻这些地区严重儿童肠胃炎健康负担的影响已得到充分记录。由于对发展中国家口服轮状病毒疫苗的性能感到担忧，在这些环境中，只有在完成了更多的临床试验和世界卫生组织于2009年发布了使用轮状病毒疫苗的全球建议之后，才开始实施疫苗。《临床传染病》增刊收录了一系列文章，介绍了早期采用轮状病毒疫苗的发展中国家常规轮状病毒疫苗接种的影响和有效性。这些数据强调了疫苗接种的益处，应为这些国家维持疫苗使用提供有价值的证据，并鼓励其他国家采用常规轮状病毒疫苗接种，以减轻严重儿童胃肠炎的健康负担。
Two rotavirus vaccines have been licensed in > 100 countries worldwide since 2006. As of October 2105, these vaccines have been implemented in the national immunization programs of 79 countries, including 36 low-income countries that are eligible for support for vaccine purchase from Gavi, the Vaccine Alliance. Rotavirus vaccines were initially introduced in Australia and countries of the Americas and Europe after completion of successful clinical trials in these regions, and the impact of routine vaccination in reducing the health burden of severe childhood gastroenteritis in these regions has been well documented. Because of concerns around the performance of orally administered rotavirus vaccines in developing countries, vaccine implementation in these settings only began after additional clinical trials were completed and the World Health Organization issued a global recommendation for use of rotavirus vaccines in 2009. This supplementary issue of Clinical Infectious Diseases includes a collection of articles describing the impact and effectiveness of routine rotavirus vaccination in developing countries that were among the early adopters of rotavirus vaccine. The data highlight the benefits of vaccination and should provide valuable evidence to sustain vaccine use in these countries and encourage other countries to adopt routine rotavirus vaccination to reduce the health burden of severe childhood gastroenteritis.