Further testing of the xerostomia inventory
Further testing of the xerostomia inventory
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DOI：
10.1016/s1079-2104(00)80013-x
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发表时间：
2000-01-01
影响因子：
--
通讯作者：
Williams, SM
中科院分区：
文献类型：
--
作者：
Thomson, WM;Williams, SM
Objective.为了检查口干症量表（XI）的同时有效性和时间稳定性，该量表是一种II项汇总评定量表，用于在流行病学和临床研究中测量口干症状的严重程度。采用前瞻性队列研究设计。使用XI和标准的口干问题（“你多久感到口干？“）在基线、2个月、4个月和6个月时对两组人进行研究。根据不同的症状轨迹选择两组：发病组（N = 57）包括即将接受头颈部癌症放疗的患者;正常组（N = 55）是一个方便的样本，中年和老年人在研究期间预计不会发生口干的变化。两组的性别分布相似，但发病组总体上比正常组年轻。发作组的基线XI评分较高。正常组的平均XI评分在观察期内没有差异，表明XI的时间稳定性可接受。发作组的评分显示基线和2个月之间显著增加，之后在研究期间的剩余时间内维持2个月水平。这些模式反映在对标准问题回答“经常”或“总是”的百分比中，为XI的同时有效性提供了进一步的证据。采用线性回归估计校正年龄、性别和两组之间初始评分差异后的最终评分差异。这被发现是9.17（95%CI 6.24，12.10），并证实接受放疗的头/颈癌与口干症的严重程度大幅增加。结论。口干症量表似乎是一种有效的多项目方法，用于测量临床和流行病学研究中口干症状的严重程度。
Objective. To examine the concurrent validity and temporal stability of the xerostomia inventory (XI), an Ii-item summated rating scale that was developed to enable measurement of the severity of dry mouth symptoms in epidemiologic and clinical studies.Study design. A prospective cohort study design was used. Measurements of the severity of dry-mouth symptoms were made with the use of the XI and a standard dry-mouth question ("How often does your mouth feel dry?") on 2 groups of people at baseline, 2, 4, and 6 months. The 2 groups were chosen for their differing symptom trajectories: the Onset group (N = 57) comprised patients who were about to undergo radiotherapy for head and neck cancer; and the Normal group (N = 55) was a convenience sample of middle-aged and older individuals who were not expected to undergo changes in mouth dryness over the study period.Results. The sex distributions of the 2 groups were similar, but the Onset group was younger than the Normal group overall. Baseline XI scores were higher among the Onset group. The mean XI scores of the Normal group did not differ over the observation period, indicating acceptable temporal stability of the XI. The scores of the Onset group showed a substantial increase between baseline and 2 months, after which the 2-month level was sustained over the remainder of the study period. That these patterns were mirrored in the percentage responding "Frequently" or "Always" to the standard question provided further evidence for the concurrent validity of the XI. Linear regression was used to estimate the difference between the final scores after adjusting for age, sex, and initial difference in scores between the 2 groups. This was found to be 9.17 (95% CI 6.24, 12.10) and confirmed that undergoing radiotherapy for head/neck cancer was associated with a substantial increase in the severity of xerostomia symptoms.Conclusion. The xerostomia inventory appears to be a valid multi-item method for measuring the severity of the symptoms of dry mouth in clinical and epidemiologic studies.