Antioxidant therapy in intensive care.
Antioxidant therapy in intensive care.
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DOI：
10.1097/00075198-200308000-00003
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发表时间：
2003-08-01
影响因子：
3.3
通讯作者：
Preiser, Jean-Charles
中科院分区：
文献类型：
--
作者：
Lovat, Robin;Preiser, Jean-Charles
审查目的：这篇综述旨在总结最近的研究结果，关于存在增加氧化应激在危重患者和其潜在的病理生理作用，以及最近的临床试验的结果抗氧化therapy.Recent调查结果：几条线的证据证实，在危重病的氧化应激增加。对细胞和组织的氧化损伤最终导致器官衰竭。预防性给予抗氧化剂维生素或谷氨酰胺，纳入营养支持或作为单独的药物，有效地减弱了氧化应激，并在一些研究中改善了危重患者的预后。在过去的两年中，N-乙酰半胱氨酸或微量元素的影响的数据很少已经公布。摘要：有器官衰竭风险的患者可以受益于早期的抗氧化剂治疗，包括维生素和谷氨酰胺。
PURPOSE OF REVIEW: This review intends to summarize the recent findings regarding the presence of increased oxidative stress in critically ill patients and its potential pathophysiologic role, as well as the results of recent clinical trials of antioxidant therapies.RECENT FINDINGS: Several lines of evidence confirm the increase in oxidative stress during critical illness. The oxidative damage to cells and tissues eventually contributes to organ failure. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as separate medications, efficiently attenuates the oxidative stress and in some studies improves the outcome of critically ill patients. Few data on the effects of N-acetylcysteine or trace elements have been published during the last two years.SUMMARY: Patients at risk of organ failure could benefit from the early adjunction of antioxidant treatment, including vitamins and glutamine.