Dissociation between the aversive and pharmacokinetic effects of ethanol in female Fischer and Lewis rats.
Dissociation between the aversive and pharmacokinetic effects of ethanol in female Fischer and Lewis rats.
复制标题
雌性 Fischer 和 Lewis 大鼠中乙醇的厌恶作用和药代动力学作用之间的分离。
DOI：
10.1016/j.bbr.2007.05.012
复制
发表时间：
2007
影响因子：
2.7
通讯作者：
Riley,AnthonyL
中科院分区：
文献类型：
--
作者：
Roma,PeterG;Chen,ScottA;Barr,ChristinaS;Riley,AnthonyL
在人类和实验室动物模型中，酒精滥用的脆弱性受到基因型等内源性因素的影响。使用近交系Fischer和刘易斯大鼠品系，我们先前报道了雄性Fischer大鼠中更强的条件性味觉厌恶（CTA），其不能通过酒精吸收的基因型差异来预测[Roma PG，Flint WW，Higley JD，Riley AL. Assessment of the aversive and rewarding effects of alcohol in Fischer and刘易斯rats. Psychopharmacology（Berl）2006;189：187-99]。本研究通过1或1.5 g/kg腹腔内（IP）乙醇诱导的四次试验CTA（n=10-12只/品系/剂量）以及1.5 g/kg IP乙醇或生理盐水注射后15、60和180 min的血液酒精浓度（BAC）测量（n=7-8只/品系/剂量），对Fischer和刘易斯雌性动物进行了类似评估。产生了剂量依赖性CTA，但这些菌株在这些测量中彼此无差异;然而，在所有三个时间点，刘易斯雌性动物的BAC均显著高于费舍尔。与Fischer和刘易斯基因型的男性一样，观察到BAC和酒精的厌恶效应之间的分离。这些数据是对Fischer和刘易斯女性中这些特定表型的首次评估，当与历史数据一起考虑时，表明在中枢介导的对酒精厌恶作用的敏感性中存在基因型×性别的相互作用。
In humans and laboratory animal models, vulnerability to alcohol abuse is influenced by endogenous factors such as genotype. Using the inbred Fischer and Lewis rat strains, we previously reported stronger conditioned taste aversions (CTA) in male Fischer rats that could not be predicted by genotypic differences in alcohol absorption [Roma PG, Flint WW, Higley JD, Riley AL. Assessment of the aversive and rewarding effects of alcohol in Fischer and Lewis rats. Psychopharmacology (Berl) 2006;189:187–99]. The present study made similar assessments in Fischer and Lewis females via four-trial CTA induced by 1 or 1.5g/kg intraperitoneal (IP) ethanol (n=10–12/strain/dose) as well as measures of blood alcohol concentrations (BAC) at 15, 60 and 180min post-injection with 1.5g/kg IP ethanol or saline (n=7–8/strain/dose). Dose-dependent CTAs were produced, but the strains did not differ from each other in these measures; however, BACs in the Lewis females were significantly higher than Fischer at all three time points. As with males of the Fischer and Lewis genotypes, a dissociation between BACs and the aversive effects of alcohol was observed. These data are the first assessments of these particular phenotypes in Fischer and Lewis females, and when considered with the historical data, suggest a Genotype×Sex interaction in the centrally mediated sensitivity to alcohol's aversive effects.