Growth hormone treatment in young children with Down's syndrome:: effects on growth and psychomotor development
Growth hormone treatment in young children with Down's syndrome:: effects on growth and psychomotor development
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DOI：
10.1136/adc.80.4.334
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发表时间：
1999-04-01
影响因子：
5.2
通讯作者：
Gustafsson, J
中科院分区：
文献类型：
--
作者：
Annerén, G;Tuvemo, T;Gustafsson, J
背景-学习障碍和身材矮小是唐氏综合征的主要症状。胰岛素样生长因子I（IGF-I）从6个月左右开始受生长激素（GH）的调节，可能参与脑发育，目的：研究GH对唐氏综合征（Down 'sSyndrome，简称唐氏综合征）幼儿线性生长和精神发育的长期影响。线性生长，精神发育，骨骼成熟，血清中IGF浓度;I和它的结合蛋白（BPs），和脑脊液（CSF）中IGF-Ⅱ的浓度进行了study.Results-The平均身高的研究组增加从-1.8到-0.8 SDS（瑞典标准）在治疗期间，而唐氏综合征对照组从-1.7下降到-2.2 SDS。停药后生长速度下降。治疗期间头部生长未加速。GH治疗后，血清IGF-I和IGFBP-3水平均恢复正常，但对头围、智力和草地运动发育无影响。停止治疗后生长速度下降。
Background-Learning disability and short stature are cardinal signs of Down's syndrome. Insulin-like growth factor I (IGF-I), regulated by growth hormone (GH) from about 6 months of age, may be involved in brain development.Aims-To study long term effects of GH on linear growth and psychomotor development in young children with Down's syndrome;Study design-Fifteen children with Down's syndrome were treated with GH for three years from the age of 6 to 9 months (mean, 7.4). Linear growth, psychomotor development, skeletal maturation, serum concentrations of IGF;I and its binding proteins (BPs), and cerebrospinal fluid (CSF) concentrations of IGF-II were studied.Results-The mean height of the study group increased from -1.8 to -0.8 SDS (Swedish standard) during treatment, whereas that of a Down's syndrome control group fell from -1.7 to -2.2 SDS. Growth velocity declined after treatment stopped. Head growth did not accelerate during treatment. No significant difference in mental or gross motor development was found. The lour concentrations of serum IGF-I and IGFBP-3 became normal during GH treatment.Conclusions-GH treatment results in normal growth velocity in Down's syndrome but does not affect head circumference or mental or grass motor development. Growth velocity declines after treatment stops.