Green tea cultivar 'Benifuuki' potentiates split vaccine-induced immunoglobulin A production
Green tea cultivar 'Benifuuki' potentiates split vaccine-induced immunoglobulin A production
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DOI：
10.1007/s11418-016-1028-7
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发表时间：
2017-01-01
影响因子：
3.3
通讯作者：
Tachibana, Hirofumi
中科院分区：
文献类型：
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作者：
Won, Yeong-Seon;Kumazoe, Motofumi;Tachibana, Hirofumi
流感是由流感病毒感染引起的一种广泛传播的疾病。接种疫苗被认为是对付流感的主要对策。分裂疫苗被广泛用于避免严重的不良事件，它诱导了强大的体液免疫。然而，单独分离疫苗不能引起粘膜免疫，包括IgA的产生，其预防作用有限。在这里，我们表明绿茶品种‘Benifuuki’提取物增强了分裂疫苗对粘膜免疫的作用。饲喂贝尼福基日粮的大鼠肺和Peyer’s patch中IgA（+）细胞的频率增加。分离疫苗免疫BALB/c小鼠，给予绿茶贝尼福提取物后，其支气管肺泡灌洗液中血凝素特异性粘膜IgA的分泌显著增加，这与病毒感染的预防密切相关。我们的研究结果表明，贝尼福基的摄入增强了分裂疫苗对粘膜免疫的作用。
Influenza is a widespread disease caused by infection with the influenza virus. Vaccination is considered to be the main countermeasure against influenza. A split vaccine is widely used to avoid severe adverse events, and it induces strong humoral immunity. However, the split vaccine alone cannot elicit mucosal immunity, including IgA production, and its preventative effects are limited. Here, we show that the green tea cultivar 'Benifuuki' extract enhanced the effect of a split vaccine on mucosal immunity. The frequency of IgA(+) cells was increased in lung and Peyer's patch that received Benifuuki diet. Secretion of hemagglutinin-specific mucosal IgA, which is closely linked to the prevention of viral infection, was significantly increased in the bronchoalveolar lavage fluid of split vaccine-immunized BALB/c mice that were administered green tea Benifuuki extract. Our findings suggest that Benifuuki intake enhanced the effects of the split vaccine on mucosal immunity.